Sensory Involvement in Amyotrophic Lateral Sclerosis

Miguel A. Rubio; Mireia Herrando-Grabulosa; Xavier Navarro

doi:10.3390/ijms232415521

Sensory Involvement in Amyotrophic Lateral Sclerosis

Miguel A. Rubio, Mireia Herrando-Grabulosa, Xavier Navarro

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives

Original language	English
Article number	15521
Number of pages	32
Journal	International journal of molecular sciences
Volume	23
Issue number	24
DOIs	https://doi.org/10.3390/ijms232415521
Publication status	Published - 8 Dec 2022

Keywords

ALS; small fiber; sensory; autonomic; proprioceptive; somatosensory

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10.3390/ijms232415521Licence: CC BY

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title = "Sensory Involvement in Amyotrophic Lateral Sclerosis",

abstract = "Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives",

keywords = "ALS; small fiber; sensory; autonomic; proprioceptive; somatosensory",

author = "Rubio, {Miguel A.} and Mireia Herrando-Grabulosa and Xavier Navarro",

note = "Funding: This work and the APC was supported by project RTI2018-096386-B-I00 of the Ministerio de Ciencia, Innovaci{\'o}n y Universidades of Spain, CIBERNED project PI2020/08-1, and TERAV (RD21/0017/0008) funds from the Instituto de Salud Carlos III of Spain, co-funded by the European Union (ERDF/ESF, “Investing in your future”).",

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AU - Herrando-Grabulosa, Mireia

AU - Navarro, Xavier

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PY - 2022/12/8

Y1 - 2022/12/8

N2 - Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives

AB - Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives

KW - ALS; small fiber; sensory; autonomic; proprioceptive; somatosensory

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VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Sensory Involvement in Amyotrophic Lateral Sclerosis

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PAPEL DEL RECEPTOR SIGMA1 EN LA MODULACION DE LAS DISFUNCIONES DE LA MEMBRANA DEL RETICULO ENDOPLASMATICO ASOCIADA A MITOCONDRIA (MAM) EN LA DEGENERACION DE MOTONEURONAS

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Sensory Involvement in Amyotrophic Lateral Sclerosis

Abstract

Keywords

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PAPEL DEL RECEPTOR SIGMA1 EN LA MODULACION DE LAS DISFUNCIONES DE LA MEMBRANA DEL RETICULO ENDOPLASMATICO ASOCIADA A MITOCONDRIA (MAM) EN LA DEGENERACION DE MOTONEURONAS

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