Sensitization of naive beagles by intradermal injection of an ascaris antigen: Induction of a model of skin allergy

R. Torres, J. Grífols, A. Marco, F. De Mora

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Ascaris suum-hypersensitive beagles represent a unique model of skin allergy. Despite its suitability, the need to test numerous dogs prior to the selection of natural positive responders causes many complications. We hypothesized that the model could be induced in adult beagles by primary sensitization. Ten dogs were included in an intradermal sensitization program using ascaris antigen and were thereafter tested for cutaneous reaction. After 2 weeks, 60% developed a positive reaction that lasted for months. We therefore present a straightforward method to establish the Ascaris canine model of allergy that will extend its availability for research in cutaneous allergy immunomodulation. Copyright © Informa Healthcare.
Original languageEnglish
Pages (from-to)697-702
JournalImmunopharmacology and Immunotoxicology
Volume28
DOIs
Publication statusPublished - 1 Oct 2006

Keywords

  • Ascaris suum antigen
  • Atopic Dermatitis
  • Canine Model
  • Intradermal Sensitization

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