Ascaris suum-hypersensitive beagles represent a unique model of skin allergy. Despite its suitability, the need to test numerous dogs prior to the selection of natural positive responders causes many complications. We hypothesized that the model could be induced in adult beagles by primary sensitization. Ten dogs were included in an intradermal sensitization program using ascaris antigen and were thereafter tested for cutaneous reaction. After 2 weeks, 60% developed a positive reaction that lasted for months. We therefore present a straightforward method to establish the Ascaris canine model of allergy that will extend its availability for research in cutaneous allergy immunomodulation. Copyright © Informa Healthcare.
|Journal||Immunopharmacology and Immunotoxicology|
|Publication status||Published - 1 Oct 2006|
- Ascaris suum antigen
- Atopic Dermatitis
- Canine Model
- Intradermal Sensitization