Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do

Jeff O'Sullivan, Mercedes Unzeta, Joe Healy, Michael I. O'Sullivan, Gavin Davey, Keith F. Tipton

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Abstract

The semicarbazide-sensitive amine oxidases (SSAO) (EC 1.4.3.6) were believed to be detoxifying enzymes, primarily involved in the oxidative deamination of endogenous amines, such as methylamine and aminoacetone, together with some xenobiotic amines. However, it appears that the reaction products may have important signalling functions in the regulation of cell development and glucose homeostasis. Furthermore, enzyme, from some sources, behaves as a cellular adhesion protein under inflammatory and it may also be involved in lipid transport. This review considers what is known about the activities and potential functions of this hardworking protein. © 2003 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)303-315
JournalNeuroToxicology
Volume25
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Aldehyde
  • Amiloride-binding protein
  • Diabetes
  • GLUT-4
  • Hydrogen peroxide
  • Monoamine oxidase
  • Semicarbazide-sensitive amine oxidase (SSAO)
  • VAP-1
  • Vascular adhesion
  • Xenobiotic

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