Semaphorins 3A and 7A: Potential immune and neuroregenerative targets in multiple sclerosis

Herena Eixarch, Ana Gutiérrez-Franco, Xavier Montalban, Carmen Espejo

Research output: Contribution to journalReview articleResearchpeer-review

26 Citations (Scopus)

Abstract

Semaphorins have been classically defined as axonal signalling cues involved in central nervous system (CNS) development, but in adults these molecules are expressed in distinct tissues and exert various functions under several physiological and pathological contexts. Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS. © 2013 Elsevier Ltd.
Original languageEnglish
Pages (from-to)157-164
JournalTrends in Molecular Medicine
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Experimental autoimmune encephalomyelitis
  • Immunomodulation
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroregeneration
  • Semaphorin

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