Self-assembly of a cyclobutane β-tetrapeptide to form nanosized structures

Federico Rúa, Stéphanie Boussert, Teodor Parella, Ismael Díez-Pérez, Vicenç Branchadell, Ernest Giralt, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)


A β-tetrapeptide made up of homochiral cyclobutane residues displays conformational bias in solution prompted by the formation of intramolecular hydrogen bonds. Moreover, this compound self-assembles to produce nanosized fibrils and, in some media, it also forms a gel. The combination of NMR, TEM, AFM, and theoretical calculations has proven to be very useful in obtaining insight into the details of these new structures. © 2007 American Chemical Society.
Original languageEnglish
Pages (from-to)3643-3645
JournalOrganic Letters
Issue number18
Publication statusPublished - 30 Aug 2007


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