TY - JOUR
T1 - Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia
AU - Martinez-Boubeta, Carlos
AU - Balcells, Lluis
AU - Cristòfol, Rosa
AU - Sanfeliu, Coral
AU - Rodríguez, Elisenda
AU - Weissleder, Ralph
AU - Lope-Piedrafita, Silvia
AU - Simeonidis, Konstantinos
AU - Angelakeris, Makis
AU - Sandiumenge, Felip
AU - Calleja, Alberto
AU - Casas, Lluis
AU - Monty, Claude
AU - Martínez, Benjamin
PY - 2010/4/1
Y1 - 2010/4/1
N2 - A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting. From the Clinical Editor: In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting. © 2010 Elsevier Inc. All rights reserved.
AB - A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting. From the Clinical Editor: In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting. © 2010 Elsevier Inc. All rights reserved.
KW - Core-shell
KW - Hyperthermia
KW - MRI
KW - Magnetism
KW - Nanoparticles
KW - Vapor condensation
U2 - 10.1016/j.nano.2009.09.003
DO - 10.1016/j.nano.2009.09.003
M3 - Article
SN - 1549-9634
VL - 6
SP - 362
EP - 370
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
ER -
