Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia

Carlos Martinez-Boubeta, Lluis Balcells, Rosa Cristòfol, Coral Sanfeliu, Elisenda Rodríguez, Ralph Weissleder, Silvia Lope-Piedrafita, Konstantinos Simeonidis, Makis Angelakeris, Felip Sandiumenge, Alberto Calleja, Lluis Casas, Claude Monty, Benjamin Martínez

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Abstract

A one-step process for the production of nanoparticles presenting advanced magnetic properties can be achieved using vapor condensation. In this article, we report on the fabrication of Fe particles covered by a uniform MgO epitaxial shell. MgO has a lower surface energy than Fe, which results in a core-shell crystal formation. The particles satisfy a few of technical requirements for the practical use in real clinics, such as a high biocompatibility in living cells in-vitro, an injection through blood vessels without any clothing problems in murine model, a high absorption rate for magnetic hyperthermia at small particle concentration, and the potential to be used as contrast agent in the field of diagnostic magnetic imaging. They are also able to be used in drug delivery and magnetic-activated cell sorting. From the Clinical Editor: In this paper, the authors report on the synthesis of Fe particles covered by a uniform MgO epitaxial shell resulting in a core-shell crystal formation. The particles are proven to be useful as contrast agents for magnetic resonance imaging and have the potential to be useful as heating mediators for cancer therapy through hyperthermia. They also might be used in drug delivery and magnetic-activated cell sorting. © 2010 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)362-370
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume6
DOIs
Publication statusPublished - 1 Apr 2010

Keywords

  • Core-shell
  • Hyperthermia
  • MRI
  • Magnetism
  • Nanoparticles
  • Vapor condensation

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