TY - JOUR
T1 - Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide
AU - Gómez-González, Jacobo
AU - Martínez-Castro, Laura
AU - Tolosa-Barrilero, Juan
AU - Alcalde-Ordóñez, Ana
AU - Learte-Aymamí, Soraya
AU - Mascareñas, José L.
AU - García-Martínez, Joaquín C.
AU - Martínez-Costas, José
AU - Maréchal, Jean-Didier
AU - López, Miguel Vázquez
AU - Vázquez, M. Eugenio
PY - 2022
Y1 - 2022
N2 - Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core
AB - Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core
U2 - 10.1039/D2CC02874C
DO - 10.1039/D2CC02874C
M3 - Article
SN - 1359-7345
VL - 58
SP - 7769
EP - 7772
JO - Chemical Communications
JF - Chemical Communications
ER -