Segmental response of the lower esophageal sphincter to increased intragastric pressure - An experimental study in cats

Carlos Bardaji, José Boix Ochoa, José Manual Pavao

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    An important controversy exists concerning the adaptive capacity of the lower esophageal sphincter (LES) in response to increases in intragastric pressure. This capacity would characterize the LES as a dynamic element in preventing gastroesophageal reflux (GER). This physiological property was studied in 15 male cats using an experimental model in which the gastroesophageal antireflux barrier was generated eyclusively by the intrinsic tone of the LES. Under these conditions, the intragastric pressure (GP) and sphincter pressure (LESP) were measured by electromanometric procedures. When the gastric lumen was perfused with known volumes (25, 50, 75, 100, 125, 150 ml) of saline solution, increases in GP and LESP were observed. Both pressures increased slowly as the gastric volume rose, and when both values were equal, GER appeared. Studying the physiological properties of the LES by direct methods in this model, we conclude that (a) there is segmental pressure response of the LES when faced with direct opening stimulation such as an increase in GP; and (b) the increase in LES resting tone has a linear relation with the increase in GP. © 1990 Springer-Verlag.
    Original languageEnglish
    Pages (from-to)106-109
    JournalPediatric Surgery International
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 1990

    Keywords

    • Esophageal manometry
    • Experimental study
    • Gastroesophageal junction
    • Lower esophageal sphincter

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