Second neoplasms in adult patients submitted to haematopoietic stem cell transplantation

Anna Torrent, Christelle Ferrá, Mireia Morgades, María José Jiménez, Juan Manuel Sancho, Susana Vives, Montserrat Batlle, Miriam Moreno, Blanca Xicoy, Albert Oriol, Gladys Ibarra, Josep Maria Ribera

Research output: Contribution to journalArticleResearchpeer-review


© 2017 Elsevier España, S.L.U. Background and objective: Patients submitted to haematopoietic stem cell transplantation (HSCT) are at increased risk of late complications, such as second neoplasm (SN). The incidence and risk factors of SN in patients receiving HSCT at a single centre were analysed. Patients and methods: The follow-up of adult patients who received a first HSCT (autologous [auto-HSCT] or allogeneic [allo-HSCT]) between January 2000 and December 2015 was reviewed. We collected their demographic characteristics, the primary disease and type of HSCT, and analysed the cumulative incidence of SN and their risk factors. Results: Of 699 transplanted patients (auto-HSCT, n = 451; allo-HSCT, n = 248), 42 (6%) developed SN (17 haematological and 25 solid), 31 post-auto-HSCT and 11 post-allo-HSCT. Haematologic SN were more frequent after auto-HSCT than after allo-HSCT. The median time between HSCT and SN was 4.09 years [range 0.07-13.15], with no differences between auto-HSCT and allo-HSCT. The cumulative incidence of SN was 5% (95% CI 3-6) at 5 years, 7% (95% CI 5-10) at 10 years and 11% (95% CI 8-15) at 15 years, without differences according to the type of HSCT. Only the age over 40 years correlated with an increased risk of SN. Conclusions: In this series, the incidence of post-HSCT SN was similar to that previously described. Patients submitted to an auto-HSCT showed a higher frequency of haematologic SN. A higher incidence of SN was detected in patients older than 40 at the time of HSCT.
Original languageEnglish
Pages (from-to)421-427
JournalMedicina Clinica
Issue number11
Publication statusPublished - 8 Jun 2018


  • Haematologic neoplasms
  • Haematopoietic stem cell transplantation
  • Second neoplasms
  • Solid tumours


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