Scalable fabrication of immunosensors based on carbon nanotube polymer composites

Ernest Mendoza, Jahir Orozco, Cecilia Jiménez-Jorquera, Ana B. González-Guerrero, Ana Calle, Laura M. Lechuga, César Fernández-Sánchez

    Research output: Contribution to journalArticleResearchpeer-review

    28 Citations (Scopus)

    Abstract

    In this work we present the fabrication and characterization of immunosensors based on polystyrene (PS)-multiwalled carbon nanotube (MWCNT) composites. The electrochemical properties of the sensors have been investigated and show that the surface area is increased upon addition of the MWCNT-PS layer. Furthermore, a plasma activation process is used to partially remove the PS and expose the MWCNTs. This results in a huge increase in the electrochemical area and opens up the possibility of binding biomolecules to the MWCNT wall. The MWCNTs have been functionalized covalently with a model antibody (rabbit IgG). The biosensors have been tested using amperometric techniques and show detection limits comparable to standard techniques such as ELISA. © IOP Publishing Ltd.
    Original languageEnglish
    Article number075102
    JournalNanotechnology
    Volume19
    Issue number7
    DOIs
    Publication statusPublished - 1 Jan 2008

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