Sativex® in multiple sclerosis spasticity: A cost-effectiveness model

John Slof, Adrien Gras

    Research output: Contribution to journalReview articleResearchpeer-review

    25 Citations (Scopus)


    Background: Multiple sclerosis (MS) is a chronic, progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and a key contributor to MS-related disability. Objectives: This study evaluated the cost-effectiveness of Sativex®, a 9-d-tetrahydrocannabinol/ cannabidiol-based oromucosal spray that acts as an endocannabinoid system modulator. Sativex was recently approved for the management of resistant MS spasticity as add-on medication. Methods: A Markov model-based analysis was performed over a 5-year horizon from a German and Spanish healthcare payer perspective. The incremental cost of Sativex was low compared with current spasticity treatments, and provided a quality-adjusted life-year gain over the current standard of care. Results: The base-case incremental cost-effectiveness ratio for Sativex was estimated at €11,214/quality-adjusted life-year in Germany, while the drug was the dominant option in Spain, providing savings of €3496/patient over a 5-year period (year of costing: 2010). This was seen because the lower severity of spasticity in patients who had improved led to reduced resource consumption (e.g., physiotherapy and medications). Conclusion: Despite having a relatively high acquisition cost, Sativex was shown to be a cost-effective treatment option for patients with MS-related spasticity. © 2012 Expert Reviews Ltd.
    Original languageEnglish
    Pages (from-to)525-538
    JournalExpert Review of Pharmacoeconomics and Outcomes Research
    Issue number4
    Publication statusPublished - 1 Aug 2012


    • cost-effectiveness
    • Delphi survey
    • healthcare costs
    • Markov model
    • multiple sclerosis
    • pharmacoeconomic analysis
    • Sativex®
    • spasticity


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