Sarilumab (IL-6R antagonist) in critically ill patients with cytokine release syndrome by SARS-CoV2.

H Corominas, I Castellví, C Diaz-Torné, L Matas, Rosa D de la, Mangues MA, P Moya, V Pomar, N Benito, E Moga, Sosa NH, J Casademont, P Domingo

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3 Citations (Scopus)

Abstract

Blocking IL-6 pathways with sarilumab, a fully human anti–IL-6R antagonist may potentially curb the inflammatory storm of SARS-CoV2. In the present emergency scenario, we used “off-label” sarilumab in 5 elderly patients in life-threatening condition not candidates to further active measures. We suggest that sarilumab can modulate severe COVID-19-associated Cytokine Release Syndrome.
Original languageUndefined/Unknown
Article numbere25923
Number of pages3
JournalMedicine
Volume100
Issue number19
DOIs
Publication statusPublished - 14 May 2021

Keywords

  • Covid-19
  • Critically ill
  • Sarilumab
  • SARS-Cov-2 infection

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