Salvage therapy with ceftolozane-tazobactam for multidrug-resistant Pseudomonas aeruginosa infections

Juan José Castón, Álvaro De La Torre, Isabel Ruiz-Camps, María Luisa Sorlí, Vicente Torres, Julián Torre-Cisneros

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Abstract

© 2017 American Society for Microbiology. All Rights Reserved. Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period. Microbiological cure in 7 patients (58.3%) was observed.
Original languageEnglish
Article numbere02136
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Ceftolozane-tazobactam
  • Pseudomonas aeruginosa
  • Salvage therapy

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