Salvage surgery after local recurrence in patients with head and neck carcinoma treated with chemoradiotherapy or bioradiotherapy

Xavier León, Adriana Agüero, Montserrat López, Jacinto García, Nuria Farré, Antonio López-Pousa, Miquel Quer

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16 Citations (Scopus)

Abstract

© 2014 Elsevier Ireland Ltd. Objective: To analyze the oncologic outcomes and surgical complications after salvage surgery for recurrence following chemoradiotherapy or bioradiotherapy for advanced head and neck squamous cell carcinoma. Methods: From 2007 to 2011, 187 patients were treated with chemoradiotherapy (. n=. 154) or bioradiotherapy (. n=. 33). Patients treated with bioradiotherapy were older and showed a tendency to poorer general condition. During the follow-up, 43 patients treated with chemoradiotherapy (27.9%) and 13 patients treated with bioradiotherapy (39.3%) had a local recurrence of the tumor. We analyzed the patient candidates to salvage surgery, and the associated complications and outcome of these surgeries. Results: Sixteen patients treated with chemoradiotherapy (37.2%) and eight treated with bioradiotherapy (61.5%) had salvage surgery. Multivariate analysis showed that the variable most strongly related to salvage surgery after local recurrence of the tumor was the type of initial treatment. The frequency of postoperative complications was higher in patients who received chemoradiotherapy (62.5% versus 12.5%, P=. 0.03). Five-year adjusted-survival after salvage surgery was 26.0% for patients receiving chemoradiotherapy and 70.0% for patients undergoing bioradiotherapy (. P=. 0.156). Conclusion: Patients who presented recurrence after bioradiotherapy were more likely candidates to salvage surgery than those who had chemoradiotherapy. Patients undergoing salvage surgery had fewer postoperative complications and better adjusted survival after bioradiotherapy than after chemoradiotherapy.
Original languageEnglish
Pages (from-to)145-149
JournalAuris Nasus Larynx
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • Bioradiotherapy
  • Cetuximab
  • Chemoradiotherapy
  • Head and neck squamous cell carcinoma
  • Salvage surgery

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