Salvage irradiation of oral and oropharyngeal cancers using interstitial radiotherapy with Au-198 grains

F. Guedea, L. Cascallar, J. Craven-Bartle, T. Eudaldo, M. Vega

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    Abstract

    Fourteen patients with recurrent or persistent carcinoma of the oral cavity or oropharynx were treated with Au-198 grain implants at the Santa Creu i Sant Pau Hospital from June 1987 through April 1991. Five patients presented recurrent carcinoma, four patients persistent carcinoma, and five patients a second primary. Local control was achieved with Au-198 implants in six patients (42.8%) at 8, 16, 23, 29, 39 and 53 months following treatment. Seven patients died of local recurrence or persistent disease at 5, 7, 7, 10, 10, 12 and 15 months after interstitial implant. Three patients (21.4%) died of significant complications of salvage irradiation (Hemorrhage in two patients and edema in one patient) at 0.5, 8 and 16 months following treatment. Three patients of fourteen (21.4%) are alive and well at 53, 39 and 23 months after salvage Au-198 grain implant. Considerations regarding the usefulness of Au-198 grain implants in the treatment of recurrent or persistent oral and oropharyngeal cancer are discussed.
    Original languageEnglish
    Pages (from-to)803-805
    JournalInternational Journal of Oncology
    Volume2
    Issue number5
    Publication statusPublished - 1 Jan 1993

    Keywords

    • Au-198 seeds
    • interstitial radiotherapy
    • oral and oropharyngeal cancers
    • salvage irradiation

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    Guedea, F., Cascallar, L., Craven-Bartle, J., Eudaldo, T., & Vega, M. (1993). Salvage irradiation of oral and oropharyngeal cancers using interstitial radiotherapy with Au-198 grains. International Journal of Oncology, 2(5), 803-805.