Safety of drug-eluting stents compared to bare metal stents in patients with an indication for long-term oral anticoagulation: A propensity score matched analysis

Javier Limeres, Gregory Y.H. Lip, Bruno García del Blanco, Ignacio Ferreira-González, Maria Mutuberria, Fernando Alfonso, Héctor Bueno, Angel Cequier, Bernard Prendergast, Javier Zueco, Oriol Rodríguez-Leor, José A. Barrabés, David García-Dorado, Antonia Sambola

Research output: Contribution to journalArticleResearch

4 Citations (Scopus)

Abstract

© 2019 Background: Drug-eluting stents (DES) reduce stent restenosis compared with bare-metal stents (BMS). However, their use in patients requiring long-term oral anticoagulation (OAC) is controversial owing to increased risk of bleeding associated with OAC plus antiplatelet treatment over time. Objective: To assess the safety of DES vs BMS in patients requiring long-term OAC for any reason. Methods: Prospective observational multicenter study conducted at 6 teaching centers of patients undergoing percutaneous coronary intervention who required OAC for any reason. Adverse outcomes were analyzed at 1 year of follow-up. Results: We identified 1002 patients requiring OAC (mean age: 72 years, male 72%). Six- hundred and thirteen patients (61.2%) received BMS and 389 (38.8%) DES. Diabetes, previous PCI, myocardial infarction and acute coronary syndrome at admission (P < 0.0001) were more common in patients with DES. Antithrombotic prescribing was similar at discharge between groups (TT: 51.5% vs 50.9%, clopidogrel plus OAC: 7.0% vs 5.0% and DAPT: 41.4% vs 42.7%, p = 0.52). DES and BMS patients showed similar rates of total bleeding (15.2% vs 13.4%, adjusted HR 0.82 [0.58–1.17, p = 0.82 and major bleeding (6.2% vs 6.0%; adjusted HR 1.22 [0.71–2.09], p = 0.46) and MACE (15.2% vs 18.6%, adjusted HR: 0.82 [0.57–1.17], p = 0.28, while restenosis was lower in patients with DES (5.3% vs 8.5%, adjusted HR. (0.52 [0.29–0.92], p = 0.02. Cox analysis after propensity score selection of 368 matched pairs demonstrated that DES use was not associated with a higher incidence of total bleeding or major bleeding. Conclusion: DES use is safe in patients with an indication for long-term OAC.
Original languageEnglish
Pages (from-to)180-186
JournalThrombosis Research
Volume177
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • Anticoagulants
  • Bleeding
  • Drug-eluting stents
  • Triple therapy

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