Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study

Paola Beltrán, Patricia Palau, Eloy Domínguez, Mercedes Faraudo, Eduardo Núñez, Olga Guri, Anna Mollar, Juan Sanchis, Antoni Bayés-Genís, Julio Núñez

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© 2017 Elsevier Ireland Ltd Background Impaired exercise capacity is the most disabling symptom in patients with heart failure with reduced ejection fraction (HFrEF). Despite sacubitril/valsartan showing reduced long-term morbidity and mortality over enalapril in HFrEF, its effects on short-term functional capacity remain uncertain. We sought to evaluate the effects of sacubitril/valsartan on a 30-day six-minute walk test in eligible patients with HFrEF. Methods and results From November 1, 2016 to February 1, 2017, a total of 58 stable symptomatic patients with HFrEF were eligible for sacubitril/valsartan and underwent 6-MWT before and 30 days after initiation of sacubitril/valsartan therapy. A mixed-effects model for repeated-measures was used to analyze the changes. Mean age was 70 ± 11 years. 72.4% males, 46.6% with ischemic heart disease, and 51.7% on NYHA functional class III were included. The mean (SD) values of baseline LVEF and 6MWT were 30 ± 7%, and 300 ± 89 m, respectively. The median (IQR) of NT-proBNP at baseline was 2701 pg/ml (1087–4200). Compared with baseline, the 6-MWT distance increased significantly at 30 days by 13.9% (+∆ = 41.8 m (33.4–50.2); p < 0.001). Conclusions In this pilot study, sacubitril/valsartan was associated with an improvement in exercise tolerance in symptomatic patients with HFrEF.
Original languageEnglish
Pages (from-to)136-139
JournalInternational Journal of Cardiology
Publication statusPublished - 1 Feb 2018


  • Exercise capacity
  • Heart failure with reduced ejection fraction
  • Sacubitril/valsartan


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