Síndrome de neurotoxicidad asociada a células inmunoefectoras: Un enfoque terapéutico en el paciente crítico

Translated title of the contribution: Immune effector cell-associated neurotoxicity syndrome: A therapeutic approach in the critically ill

J. C. Suarez Montero*, A. C. Caballero Gonzalez, L. Martín Aguilar, J. Mancebo Cortés

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)

Abstract

Immunotherapy with chimeric antigen-specific receptor modified T cells, known as CAR-T, is emerging as a promising approach to hematological malignancies. In this regard, CAR-T against human cluster of differentiation (CD) 19 has demonstrated antitumor efficacy in application to B cell neoplasms resistant to conventional therapy. However, activation of the immune system induces severe and specific complications which can prove life-threatening. These include cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (known as ICANS) - the latter being the subject of the present review. Although the physiopathological mechanisms underlying ICANS are not well known, a number of clinical and biological factors increase the risk of developing neurotoxicity associated to CAR-T therapy. Treatment is based on close monitoring, measures of support, anticonvulsivants, corticosteroids, and early admission to intensive care. The present study offers a comprehensive review of the available literature from a multidisciplinary perspective, including recommendations from intensivists, neurologists and hematologists dedicated to the care of critically ill adults.

Translated title of the contributionImmune effector cell-associated neurotoxicity syndrome: A therapeutic approach in the critically ill
Original languageSpanish
Pages (from-to)201-212
Number of pages12
JournalMedicina Intensiva
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 2022

Fingerprint

Dive into the research topics of 'Immune effector cell-associated neurotoxicity syndrome: A therapeutic approach in the critically ill'. Together they form a unique fingerprint.

Cite this