Síndrome antifosfolipídico obstétrico

Translated title of the contribution: Obstetric antiphospholipid syndrome

E Esteve-Valverde, R Ferrer-Oliveras, J Alijotas-Reig

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)


Obstetric antiphospholipid syndrome is an acquired autoimmune disorder that is associated with various obstetric complications and, in the absence of prior history of thrombosis, with the presence of antiphospholipid antibodies directed against other phospholipids, proteins called cofactors or PL-cofactor complexes. Although the obstetric complications have been related to the procoagulant properties of antiphospholipid antibodies, pathological studies of human placenta have shown the proinflammatory capacity of antiphospholipid antibodies via the complement system and proinflammatory cytokines. There is no general agreement on which antiphospholipid antibodies profile (laboratory) confers the greatest obstetric risk, but the best candidates are categories I and IIa. Combined treatment with low doses of aspirin and heparin achieves good obstetric and maternal outcomes. In this study, we also review the therapeutic possibilities in refractory cases, although the likelihood of progressing to other autoimmune diseases is low. We briefly comment on incomplete obstetric antiphospholipid syndrome, also known as antiphospholipid antibody-mediated pregnancy morbidity syndrome.

Translated title of the contributionObstetric antiphospholipid syndrome
Original languageSpanish
Pages (from-to)135-45
Number of pages11
JournalRevista clínica espanõla
Issue number3
Publication statusPublished - Apr 2016


Dive into the research topics of 'Obstetric antiphospholipid syndrome'. Together they form a unique fingerprint.

Cite this