Ruthenium-catalyzed asymmetric hydrogenation of N-(3,4-dihydro-2-naphthalenyl)-acetamide

Xavier Sala, Isabel Serrano, Montserrat Rodríguez, Isabel Romero, Antoni Llobet, Piet W.N.M. van Leeuwen

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)


The enantioselective hydrogenation of a challenging enamide (N-(3,4-dihydro-2-naphthalenyl)-acetamide, 1) bearing an endocyclic trisubstituted carbon-carbon double bond has been performed using cis-fac-Δ-[RuIICl{(R)-(bpea)}{(S)-(BINAP)}] BF4, cis-fac-Δ-(R)-(S)-3, as catalyst achieving good conversions and enantioselectivities up to 74%. Furthermore, the study of the influence of different reaction parameters during the hydrogenation reaction has been performed, showing a strong influence of the coordinating ability of the solvent on the reaction rate. © 2007 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)117-119
JournalCatalysis Communications
Issue number1
Publication statusPublished - 1 Jan 2008


  • Asymmetric catalysis
  • Enamide hydrogenation
  • Ruthenium


Dive into the research topics of 'Ruthenium-catalyzed asymmetric hydrogenation of N-(3,4-dihydro-2-naphthalenyl)-acetamide'. Together they form a unique fingerprint.

Cite this