Rupatadine 20 mg and 40 mg are effective in reducing the symptoms of chronic cold urticaria

Marina Abajian, Laia Curto-Barredo, Karoline Krause, Eva Santamaria, Iñaki Izquierdo, Martin K. Church, Marcus Maurer, Ana Giménez-Arnau

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    19 Citations (Scopus)

    Abstract

    © 2016 The Authors. and 2016 Acta Dermato-Venereologica. Chronic cold urticaria (ColdU) is a rare disease characterized by mast cell-mediated wheals and angioedema following cold exposure. Second-generation H1-antihistamines, such as rupatadine, are the recommended first-line therapy. As of yet, the effects of rupatadine up-dosing on development of ColdU symptom have only been partially characterized. Two-centre, randomized, double-blind, 3-way crossover, placebo-controlled study in patients with a confirmed ColdU was designed to assess the effects of up-dosing of rupatadine. A total of 23 patients were randomized to receive placebo, rupatadine 20 mg/day, and rupatadine 40 mg/day for 1 week. The primary outcome was change in critical temperature thresholds and critical stimulation time thresholds after treatment. Secondary endpoints included assessment of safety and tolerability of rupatadine. Both 20 and 40 mg rupatadine were highly effective in reducing critical temperature thresholds (p < 0.001) and critical stimulation time thresholds (p < 0.001). In conclusion, rupatadine 20 and 40 mg significantly reduced the development of chronic cold urticaria symptom without an increase in adverse effects.
    Original languageEnglish
    Pages (from-to)56-59
    JournalActa Dermato-Venereologica
    Volume96
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2016

    Keywords

    • Chronic cold urticarial
    • H1-antihistamine
    • Rupatadine
    • Up-dosing

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  • Cite this

    Abajian, M., Curto-Barredo, L., Krause, K., Santamaria, E., Izquierdo, I., Church, M. K., Maurer, M., & Giménez-Arnau, A. (2016). Rupatadine 20 mg and 40 mg are effective in reducing the symptoms of chronic cold urticaria. Acta Dermato-Venereologica, 96(1), 56-59. https://doi.org/10.2340/00015555-2150