Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors

Miquel Casas; Sergi Ferré; Josep Cadafalch; Josep M. Grau; Francesc Jané

doi:10.1016/0091-3057(89)90396-1

Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors

Miquel Casas, Sergi Ferré, Josep Cadafalch, Josep M. Grau, Francesc Jané

Department of Psychiatry and Legal Medicine

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Abstract

We studied apomorphine- and theophyslline-induced rotational behaviour in rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway. It was seen that there was a direct correlation between the number of apomorphine- and theophylline-induced contralateral turns. These data suggest the existence of a relationship between theophylline-induced rotational behaviour and the degree of supersensitivity of the striatal dopaminergic receptors. Because the rotational behaviour induced by theophylline is in the same direction as dopaminergic agonists, contralateral to the nigrostriatal pathway lesion, these results suggest the possibility of a direct dopaminergic agonism of methylxanthines. © 1989.

Original language	English
Pages (from-to)	609-613
Journal	Pharmacology, Biochemistry and Behavior
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(89)90396-1
Publication status	Published - 1 Jan 1989

Keywords

Apomorphine
Behavioural supersensitivity
Rotation
Theophylline

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10.1016/0091-3057(89)90396-1

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title = "Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors",

abstract = "We studied apomorphine- and theophyslline-induced rotational behaviour in rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway. It was seen that there was a direct correlation between the number of apomorphine- and theophylline-induced contralateral turns. These data suggest the existence of a relationship between theophylline-induced rotational behaviour and the degree of supersensitivity of the striatal dopaminergic receptors. Because the rotational behaviour induced by theophylline is in the same direction as dopaminergic agonists, contralateral to the nigrostriatal pathway lesion, these results suggest the possibility of a direct dopaminergic agonism of methylxanthines. {\textcopyright} 1989.",

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Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors. / Casas, Miquel; Ferré, Sergi; Cadafalch, Josep et al.
In: Pharmacology, Biochemistry and Behavior, Vol. 33, No. 3, 01.01.1989, p. 609-613.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors

AU - Casas, Miquel

AU - Ferré, Sergi

AU - Cadafalch, Josep

AU - Grau, Josep M.

AU - Jané, Francesc

PY - 1989/1/1

Y1 - 1989/1/1

N2 - We studied apomorphine- and theophyslline-induced rotational behaviour in rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway. It was seen that there was a direct correlation between the number of apomorphine- and theophylline-induced contralateral turns. These data suggest the existence of a relationship between theophylline-induced rotational behaviour and the degree of supersensitivity of the striatal dopaminergic receptors. Because the rotational behaviour induced by theophylline is in the same direction as dopaminergic agonists, contralateral to the nigrostriatal pathway lesion, these results suggest the possibility of a direct dopaminergic agonism of methylxanthines. © 1989.

AB - We studied apomorphine- and theophyslline-induced rotational behaviour in rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway. It was seen that there was a direct correlation between the number of apomorphine- and theophylline-induced contralateral turns. These data suggest the existence of a relationship between theophylline-induced rotational behaviour and the degree of supersensitivity of the striatal dopaminergic receptors. Because the rotational behaviour induced by theophylline is in the same direction as dopaminergic agonists, contralateral to the nigrostriatal pathway lesion, these results suggest the possibility of a direct dopaminergic agonism of methylxanthines. © 1989.

KW - Apomorphine

KW - Behavioural supersensitivity

KW - Rotation

KW - Theophylline

U2 - 10.1016/0091-3057(89)90396-1

DO - 10.1016/0091-3057(89)90396-1

M3 - Article

SN - 0091-3057

VL - 33

SP - 609

EP - 613

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 3

ER -

Rotational behaviour induced by theophylline in 6-OHDA nigrostriatal denervated rats is dependent on the supersensitivity of striatal dopaminergic receptors

Abstract

Keywords

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