Role of Xanthine Oxidase and Eicosanoids in Development of Pancreatic Ischemia-Reperfusion Injury

G. Hotter, D. Closa, E. Gelpí, N. Prats, J. Roselló-Catafau

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    13 Citations (Scopus)

    Abstract

    The implication of different eicosanoids and oxygen free radicals in the development of pancreatic injury after an ischemia-reperfusion process has been evaluated. For this purpose we have compared the effect of allopurinol and indomethacin administration on the pancreatic levels of eicosanoids in a rat model of pancreatic ischemia-reperfusion. After 60 min of pancreatic ischemia and 2 h of reperfusion, significant increases in 6-keto-PGF1α, PGE2, and LTB4 in pancreas tissue were detected. Allopurinol before the ischemic period reduced 6-keto-PGF1α, PGE2, and LTB4 levels to the range of basal values, while prior indomethacin treatment significantly reduced 6-keto-PGF1α and PGE2 levels, with LTB4 remaining unmodified. Increased postischemic plasma lipases were also significantly reduced by allopurinol to the range of sham-operated animals whereas indomethacin did not modify these levels. The data suggest a role for lipoxygenase metabolites in the development of pancreatic injury and the importance of the enzyme xanthine oxidase as an inductor of eicosanoid biosynthesis. © 1995 Plenum Publishing Corporation.
    Original languageEnglish
    Pages (from-to)469-478
    JournalInflammation
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - 1 Aug 1995

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