TY - JOUR
T1 - Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence
AU - Campoy, Susana
AU - Jara, Mónica
AU - Busquets, Núria
AU - Pérez De Rozas, Ana M.
AU - Badiola, Ignacio
AU - Barbé, Jordi
PY - 2002/7/30
Y1 - 2002/7/30
N2 - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
AB - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
U2 - 10.1128/IAI.70.8.4721-4725.2002
DO - 10.1128/IAI.70.8.4721-4725.2002
M3 - Article
VL - 70
SP - 4721
EP - 4725
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 8
ER -