Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

Susana Campoy, Mónica Jara, Núria Busquets, Ana M. Pérez De Rozas, Ignacio Badiola, Jordi Barbé

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Abstract

The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
Original languageEnglish
Pages (from-to)4721-4725
JournalInfection and Immunity
Volume70
Issue number8
DOIs
Publication statusPublished - 30 Jul 2002

Fingerprint Dive into the research topics of 'Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence'. Together they form a unique fingerprint.

Cite this