Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

Susana Campoy; Mónica Jara; Núria Busquets; Ana M. Pérez De Rozas; Ignacio Badiola; Jordi Barbé

doi:10.1128/IAI.70.8.4721-4725.2002

Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

Susana Campoy, Mónica Jara, Núria Busquets, Ana M. Pérez De Rozas, Ignacio Badiola, Jordi Barbé

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

107 Citations (Scopus)

Abstract

The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

Original language	English
Pages (from-to)	4721-4725
Journal	Infection and Immunity
Volume	70
Issue number	8
DOIs	https://doi.org/10.1128/IAI.70.8.4721-4725.2002
Publication status	Published - 30 Jul 2002

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abstract = "The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.",

author = "Susana Campoy and M{\'o}nica Jara and N{\'u}ria Busquets and {P{\'e}rez De Rozas}, {Ana M.} and Ignacio Badiola and Jordi Barb{\'e}",

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T1 - Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

AU - Campoy, Susana

AU - Jara, Mónica

AU - Busquets, Núria

AU - Pérez De Rozas, Ana M.

AU - Badiola, Ignacio

AU - Barbé, Jordi

PY - 2002/7/30

Y1 - 2002/7/30

N2 - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

AB - The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

U2 - 10.1128/IAI.70.8.4721-4725.2002

DO - 10.1128/IAI.70.8.4721-4725.2002

M3 - Article

VL - 70

SP - 4721

EP - 4725

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 8

ER -