Role of glucocorticoids and catecholamines on hepatic thiobarbituric acid reactants in basal and stress conditions in the rat

Juan Hidalgo*, T. Gasull, A. Garcia, A. Blanquez, A. Armario

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    15 Citations (Scopus)

    Abstract

    Thiobarbituric acid-reactants (TBARs) are considered to be an index of lipid peroxidation. In the present experiments, the effect of stress and hormones on hepatic TBARs levels was studied in Sprague-Dawley rats. In unstressed conditions adrenalectomized rats showed higher TBARs levels than sham-adrenalectomized rats. The effect of adrenalectomy was reverted by the administration of corticosterone but not by that of aldosterone, indicating that glucocorticoids exert a negative role on the regulation of liver TBARs. The effect of these hormones appears to be a permissive one, since the administration of a long lasting ACTH preparation did not reduce liver TBARs. In contrast to that observed in unstressed rats, glucocorticoids appeared to increase liver TBARs in stressed rats. Nevertheless, other alternative explanations are possible. Finally, no evidence for a role of catecholamines in the regulation of hepatic TBARs was found.
    Original languageEnglish
    Pages (from-to)104-109
    JournalHormone and Metabolic Research
    Volume23
    DOIs
    Publication statusPublished - 1 Jan 1991

    Keywords

    • Adrenalectomy
    • Catecholamines
    • Free radicals
    • Gastric ulceration
    • Glucocorticoids
    • Hepatic lipid peroxidation
    • Mineralo corticoids
    • Stress

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