TY - JOUR
T1 - Role of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal tuberculosis
AU - Chalela, Roberto
AU - Sánchez-Font, Albert
AU - Domínguez-Álvarez, Marisol
AU - Badenes-Bonet, Diana
AU - Pijuan, Lara
AU - Curull, Víctor
PY - 2016/6/17
Y1 - 2016/6/17
N2 - © 2016 Elsevier España, S.L.U. Introduction Mediastinal tuberculosis (TB) is rare and a diagnostic challenge. Transbronchial needle aspiration guided by endoscopic ultrasonography (EBUS-TBNA) is an essential tool for staging and diagnosing patients with lung cancer but to date there are no studies in our environment evaluating its efficacy in mediastinal TB. Methods Patients with a final diagnosis of isolated intrathoracic tuberculous lymphadenitis over a 6-year period were included. We analyzed the cases on whom EBUS-TBNA was performed. Results Forty-six patients with mediastinal lymphadenopathy without pulmonary involvement were identified and 29 underwent EBUS-TBNA. In 28 of 29 patients (96.6%) EBUS-TBNA was diagnostic and cytological findings confirmed granulomas in 93% of cases. Microbiological investigation revealed positive TB culture in 14 (48.2%) and positive PCR for Mycobacterium tuberculosis in 30% of cases on whom it was carried out. Eighty-four per cent of the patients were immigrants and when compared with the native population we found statistical differences in immune status and culture yield. Conclusion EBUS-TBNA is a safe and effective technique in the diagnosis of patients with suspected mediastinal TB.
AB - © 2016 Elsevier España, S.L.U. Introduction Mediastinal tuberculosis (TB) is rare and a diagnostic challenge. Transbronchial needle aspiration guided by endoscopic ultrasonography (EBUS-TBNA) is an essential tool for staging and diagnosing patients with lung cancer but to date there are no studies in our environment evaluating its efficacy in mediastinal TB. Methods Patients with a final diagnosis of isolated intrathoracic tuberculous lymphadenitis over a 6-year period were included. We analyzed the cases on whom EBUS-TBNA was performed. Results Forty-six patients with mediastinal lymphadenopathy without pulmonary involvement were identified and 29 underwent EBUS-TBNA. In 28 of 29 patients (96.6%) EBUS-TBNA was diagnostic and cytological findings confirmed granulomas in 93% of cases. Microbiological investigation revealed positive TB culture in 14 (48.2%) and positive PCR for Mycobacterium tuberculosis in 30% of cases on whom it was carried out. Eighty-four per cent of the patients were immigrants and when compared with the native population we found statistical differences in immune status and culture yield. Conclusion EBUS-TBNA is a safe and effective technique in the diagnosis of patients with suspected mediastinal TB.
KW - EBUS-TBNA
KW - Endobronchial ultrasound
KW - Intrathoracic tuberculous lymphadenitis
U2 - 10.1016/j.medcli.2016.02.027
DO - 10.1016/j.medcli.2016.02.027
M3 - Article
VL - 146
SP - 532
EP - 535
JO - Medicina Clinica
JF - Medicina Clinica
SN - 0025-7753
IS - 12
ER -