RNA interference of HIV replication

Research output: Contribution to journalReview articleResearchpeer-review

69 Citations (Scopus)


Double-stranded RNA-mediated interference (RNAi) induces sequence-specific post-transcriptional gene silencing and has emerged as a powerful tool to silence gene expression in multiple organisms. In mammalian cells, duplexes of 21 nucleotide RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression. Recent research demonstrates the general use of siRNAs to specifically inhibit HIV-1 replication by targeting viral or cellular genes. Importantly, RNAi opens a new avenue for gene-based therapeutics.
Original languageEnglish
Pages (from-to)559-561
JournalTrends in Immunology
Issue number12
Publication statusPublished - 1 Dec 2002


Dive into the research topics of 'RNA interference of HIV replication'. Together they form a unique fingerprint.

Cite this