RNA interference of HIV replication

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69 Citations (Scopus)

Abstract

Double-stranded RNA-mediated interference (RNAi) induces sequence-specific post-transcriptional gene silencing and has emerged as a powerful tool to silence gene expression in multiple organisms. In mammalian cells, duplexes of 21 nucleotide RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression. Recent research demonstrates the general use of siRNAs to specifically inhibit HIV-1 replication by targeting viral or cellular genes. Importantly, RNAi opens a new avenue for gene-based therapeutics.
Original languageEnglish
Pages (from-to)559-561
JournalTrends in Immunology
Volume23
Issue number12
DOIs
Publication statusPublished - 1 Dec 2002

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