TY - JOUR
T1 - Risk of onset of second neoplasms and successive neoplasms in patients with a head and neck index tumour
AU - León, Xavier
AU - García, Jacinto
AU - López, Montserrat
AU - Rodriguez, Camilo
AU - Gutierrez, Alfons
AU - Quer, Miquel
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2019 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello Objective: To analyse the incidence of appearance of second and successive neoplasms in a cohort of head and neck squamous carcinoma patients. Material and methods: We conducted a retrospective study with 4,458 patients with an index tumour located in the head and neck diagnosed during the 1985-2016 period. We evaluated the incidence of appearance of second neoplasms and successive neoplasms over a period of 30 years. Results: During the follow-up, 1,203 patients (27.0%) had a second neoplasm, 242 patients (5.4%) a third neoplasm, 58 patients (1.3%) a fourth neoplasm, and 8 patients (0.2%) 5 or more successive neoplasms. The incidence of appearance of second neoplasms was 3.5% per year, remaining relatively constant throughout the follow-up period. The patients with a second neoplasm had a higher risk of appearance of a third neoplasm, and those with a third neoplasm had a higher risk of a fourth. Seventy-eight percent of the second neoplasms, 88% of the third neoplasms, and 89.6% of the fourth neoplasms appeared in locations epidemiologically related to tobacco and alcohol use. Conclusions: Second neoplasms after a head and neck index tumour appeared at a constant rate of 3.5% per year throughout the entire follow-up period.
AB - © 2019 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello Objective: To analyse the incidence of appearance of second and successive neoplasms in a cohort of head and neck squamous carcinoma patients. Material and methods: We conducted a retrospective study with 4,458 patients with an index tumour located in the head and neck diagnosed during the 1985-2016 period. We evaluated the incidence of appearance of second neoplasms and successive neoplasms over a period of 30 years. Results: During the follow-up, 1,203 patients (27.0%) had a second neoplasm, 242 patients (5.4%) a third neoplasm, 58 patients (1.3%) a fourth neoplasm, and 8 patients (0.2%) 5 or more successive neoplasms. The incidence of appearance of second neoplasms was 3.5% per year, remaining relatively constant throughout the follow-up period. The patients with a second neoplasm had a higher risk of appearance of a third neoplasm, and those with a third neoplasm had a higher risk of a fourth. Seventy-eight percent of the second neoplasms, 88% of the third neoplasms, and 89.6% of the fourth neoplasms appeared in locations epidemiologically related to tobacco and alcohol use. Conclusions: Second neoplasms after a head and neck index tumour appeared at a constant rate of 3.5% per year throughout the entire follow-up period.
KW - Index tumour
KW - Second neoplasms
KW - Squamous carcinoma of head and neck
KW - Successive neoplasms
U2 - 10.1016/j.otorri.2018.11.003
DO - 10.1016/j.otorri.2018.11.003
M3 - Article
C2 - 30987756
JO - Acta Otorrinolaringologica Espanola
JF - Acta Otorrinolaringologica Espanola
SN - 0001-6519
ER -