Risk factors prospectively associated with adult obsessive-compulsive symptom dimensions and obsessive-compulsive disorder

J. R. Grisham, M. A. Fullana, D. Mataix-Cols, T. E. Moffitt, A. Caspi, R. Poulton

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Background Very few longitudinal studies have evaluated prospective neurodevelopmental and psychosocial risk factors for obsessive-compulsive disorder (OCD). Furthermore, despite the heterogeneous nature of OCD, no research has examined risk factors for its primary symptom dimensions, such as contamination/washing.Method Potential risk factors for symptoms or diagnosis of OCD in adulthood and for specific adult obsessive-compulsive (OC) symptom dimensions were examined in the Dunedin Study birth cohort. The presence of obsessions and compulsions and psychological disorders was assessed using the Diagnostic Interview Schedule (DIS) at ages 26 and 32 years. Individuals with a diagnosis of OCD at either age (n=36) were compared to both a healthy control group (n=613) and an anxious control group (n=310) to determine whether associations between a risk factor and an OCD diagnosis were specific.Results Childhood neurodevelopmental, behavioral, personality and environmental risk factors were associated with a diagnosis of OCD and with OC symptoms at ages 26 and 32. Social isolation, retrospectively reported physical abuse and negative emotionality were specific predictors of an adult OCD diagnosis. Of note, most risk factors were associated with OC symptoms in adulthood and several risk factors predicted specific OCD dimensions. Perinatal insults were linked to increased risk for symmetry/ordering and shameful thoughts dimensions, whereas poor childhood motor skills predicted the harm/checking dimension. Difficult temperament, internalizing symptoms and conduct problems in childhood also predicted specific symptom dimensions and lower IQ non-specifically predicted increased risk for most dimensions.Conclusions The current findings underscore the need for a dimensional approach in evaluating childhood risk factors for obsessions and compulsions. © 2011 Cambridge University Press.
Original languageEnglish
Pages (from-to)2495-2506
JournalPsychological Medicine
Issue number12
Publication statusPublished - 1 Dec 2011


  • Anxiety disorders
  • longitudinal
  • obsessive-compulsive disorder
  • prospective


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