Risk factors for posttraumatic stress disorder: An umbrella review of systematic reviews and meta-analyses

Miquel Tortella-Feliu, Miquel A. Fullana, Ana Pérez-Vigil, Xavier Torres, Jacobo Chamorro, Sergio A. Littarelli, Aleix Solanes, Valentina Ramella-Cravaro, Ana Vilar, José A. González-Parra, Raül Andero, Prof Abraham Reichenberg, Prof David Mataix-Cols, Eduard Vieta, Paolo Fusar-Poli, Prof John P.A. Ioannidis, Prof Murray B. Stein, Joaquim Radua, Lorena Fernández de la Cruz

Research output: Contribution to journalReview articleResearchpeer-review

9 Citations (Scopus)

Abstract

Approximately one third of individuals who experience a severe traumatic event will develop posttraumatic stress disorder (PTSD). It is crucial to identify what factors may be associated with increased or decreased risk for PTSD. We conducted an umbrella review of systematic reviews and meta-analyses of risk/protective factors for PTSD and assessed and graded the evidence of the association between each factor and PTSD. Thirty-three systematic reviews and meta-analyses were included and 130 potential risk factors were identified. Of those, 57 showed a significant association with PTSD. Being female or being indigenous people of the Americas, among the sociodemographic factors; history of physical disease and family history of psychiatric disorder, among the pretrauma factors; and cumulative exposure to potentially traumatic experiences, trauma severity, and being trapped during an earthquake, among the peritrauma factors, showed convincing or highly suggestive evidence of an association with PTSD. Data from prospective studies were less conclusive. Our results have the potential of helping refine PTSD prediction models and contributing to the design of prevention strategies.
Original languageEnglish
Pages (from-to)154-165
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Volume107
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • ADULTS
  • ANXIETY DISORDERS
  • DEPRESSION
  • DISASTERS
  • INJURY
  • MENTAL-HEALTH
  • PREDICTORS
  • PREVALENCE
  • SURVIVORS
  • TRAUMA

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