Risk factors for candidaemia in critically ill patients: A prospective surveillance study

Ricard Jordà-Marcos; Francisco Álvarez-Lerma; Maite Jurado; Mercedes Palomar; Juan Nolla-Salas; María A. León; Cristóbal León; J. Nolla; F. Álvarez-Lerma; M. Salvadó; N. Carrasco; A. Bueno; F. Bobillo; P. Ucio; M. A. León; M. Nolla; R. A. Díaz; J. R. Iruretagoyena; K. Esnaola; I. Andetxaga; A. Blanco; F. Taboada; R. Fernández; M. Nieto; R. Diego; F. Ortuño; P. Marcos; E. Mesalles; A. Martínez; M. Fernández; F. Jaime; H. Sancho; N. Izquierdo; M. Ulibarrena; F. Labayen; F. Barcenilla; M. J. Gil; B. Balsera; R. Jordá; Maite Jurado; J. Pérez; E. Zavala; A. Alcón; N. Fabregues; M. V. De La Torre; M. A. Estecha; A. Soler; M. Bodí; D. Castander; A. Mendía; J. Artaetxebarría; C. Reviejo; M. Sánchez; A. Casamitjana; C. Pérez; M. J. López; E. Robles; Y. Insausti; J. A. Tihistsa; C. García; J. M. Rubio; R. Oltra; O. Rodríguez; P. Olaechea; R. De Celís; J. M. Soto; J. Pomares; J. Luna; G. Masdeu; R. Sierra; A. Gordillo; R. Rodríguez; J. Fajardo; M. A. Herranz; J. I. Gómez; R. M. García; M. J. Espina; J. Garnacho; C. Ortiz; M. Palomar; J. Montero J; C. Cisneros; A. Sandiumenje; M. Sánchez; M. Álvarez; V. López; R. Julve; J. Solé; M. Valerón; M. A. Blasco; S. Borrás; E. Maraví; J. M. Urtasun; C. Sánchez-Díaz; L. M. Tamayo; J. Blanco; P. Galdós; F. Barredo; A. Rodríguez; J. Castaño

doi:10.1111/j.1439-0507.2007.01366.x

Risk factors for candidaemia in critically ill patients: A prospective surveillance study

Ricard Jordà-Marcos, Francisco Álvarez-Lerma, Maite Jurado, Mercedes Palomar, Juan Nolla-Salas, María A. León, Cristóbal León, J. Nolla, F. Álvarez-Lerma, M. Salvadó, N. Carrasco, A. Bueno, F. Bobillo, P. Ucio, M. A. León, M. Nolla, R. A. Díaz, J. R. Iruretagoyena, K. Esnaola, I. AndetxagaA. Blanco, F. Taboada, R. Fernández, M. Nieto, R. Diego, F. Ortuño, P. Marcos, E. Mesalles, A. Martínez, M. Fernández, F. Jaime, H. Sancho, N. Izquierdo, M. Ulibarrena, F. Labayen, F. Barcenilla, M. J. Gil, B. Balsera, R. Jordá, Maite Jurado, J. Pérez, E. Zavala, A. Alcón, N. Fabregues, M. V. De La Torre, M. A. Estecha, A. Soler, M. Bodí, D. Castander, A. Mendía, J. Artaetxebarría, C. Reviejo, M. Sánchez, A. Casamitjana, C. Pérez, M. J. López, E. Robles, Y. Insausti, J. A. Tihistsa, C. García, J. M. Rubio, R. Oltra, O. Rodríguez, P. Olaechea, R. De Celís, J. M. Soto, J. Pomares, J. Luna, G. Masdeu, R. Sierra, A. Gordillo, R. Rodríguez, J. Fajardo, M. A. Herranz, J. I. Gómez, R. M. García, M. J. Espina, J. Garnacho, C. Ortiz, M. Palomar, J. Montero J, C. Cisneros, A. Sandiumenje, M. Sánchez, M. Álvarez, V. López, R. Julve, J. Solé, M. Valerón, M. A. Blasco, S. Borrás, E. Maraví, J. M. Urtasun, C. Sánchez-Díaz, L. M. Tamayo, J. Blanco, P. Galdós, F. Barredo, A. Rodríguez, J. Castaño

Research output: Contribution to journal › Article › Research › peer-review

76 Citations (Scopus)

Abstract

Candidaemia is frequently a life-threatening complication in patients admitted to the intensive care unit (ICU). To assess the risk factors for candidaemia in critically ill patients with prolonged ICU stay, a total of 1765 adult patients admitted for at least 7 days to 73 medical-surgical ICUs of 70 tertiary care hospitals in Spain participated in a prospective cohort study. Candidaemia was defined as recovery of Candida spp. from blood culture. Sixty-eight episodes of candidaemia occurred in 63 patients, representing 35.7 episodes per 1000 ICU patients admitted, with an incidence rate of 1.5 episodes per 1000 days of ICU stay. Causative fungi were C. albicans in 57.1% of cases and non-albicansCandida spp. in 42.9%. In the multivariate analysis, independent factors significantly associated with candidaemia were Candida colonisation (OR = 4.12, 95% CI: 1.82-9.33), total parenteral nutrition (OR = 3.89, 95% CI: 1.73-8.78), elective surgery (OR = 2.75, 95% CI: 1.17-6.45) and haemofiltration procedures (OR = 1.96, 95% CI: 1.06-3.62). In the ICU setting in Spain and in patients who have stayed in units for >7 days, more than half of cases of candidaemia were caused by C. albicans. Risk factors for candidaemia identified included Candida colonisation, elective surgery, total parenteral nutrition and haemodialysis. © 2007 The Authors.

Original language	English
Pages (from-to)	302-310
Journal	Mycoses
Volume	50
Issue number	4
DOIs	https://doi.org/10.1111/j.1439-0507.2007.01366.x
Publication status	Published - 1 Jul 2007

Keywords

Candida colonisation
Candidaemia
Critically ill patients
Intensive care unit
Risk factors

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10.1111/j.1439-0507.2007.01366.x

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Jordà-Marcos, R., Álvarez-Lerma, F., Jurado, M., Palomar, M., Nolla-Salas, J., León, M. A., León, C., Nolla, J., Álvarez-Lerma, F., Salvadó, M., Carrasco, N., Bueno, A., Bobillo, F., Ucio, P., León, M. A., Nolla, M., Díaz, R. A., Iruretagoyena, J. R., Esnaola, K., ... Castaño, J. (2007). Risk factors for candidaemia in critically ill patients: A prospective surveillance study. Mycoses, 50(4), 302-310. https://doi.org/10.1111/j.1439-0507.2007.01366.x

Jordà-Marcos, Ricard ; Álvarez-Lerma, Francisco ; Jurado, Maite ; Palomar, Mercedes ; Nolla-Salas, Juan ; León, María A. ; León, Cristóbal ; Nolla, J. ; Álvarez-Lerma, F. ; Salvadó, M. ; Carrasco, N. ; Bueno, A. ; Bobillo, F. ; Ucio, P. ; León, M. A. ; Nolla, M. ; Díaz, R. A. ; Iruretagoyena, J. R. ; Esnaola, K. ; Andetxaga, I. ; Blanco, A. ; Taboada, F. ; Fernández, R. ; Nieto, M. ; Diego, R. ; Ortuño, F. ; Marcos, P. ; Mesalles, E. ; Martínez, A. ; Fernández, M. ; Jaime, F. ; Sancho, H. ; Izquierdo, N. ; Ulibarrena, M. ; Labayen, F. ; Barcenilla, F. ; Gil, M. J. ; Balsera, B. ; Jordá, R. ; Jurado, Maite ; Pérez, J. ; Zavala, E. ; Alcón, A. ; Fabregues, N. ; De La Torre, M. V. ; Estecha, M. A. ; Soler, A. ; Bodí, M. ; Castander, D. ; Mendía, A. ; Artaetxebarría, J. ; Reviejo, C. ; Sánchez, M. ; Casamitjana, A. ; Pérez, C. ; López, M. J. ; Robles, E. ; Insausti, Y. ; Tihistsa, J. A. ; García, C. ; Rubio, J. M. ; Oltra, R. ; Rodríguez, O. ; Olaechea, P. ; De Celís, R. ; Soto, J. M. ; Pomares, J. ; Luna, J. ; Masdeu, G. ; Sierra, R. ; Gordillo, A. ; Rodríguez, R. ; Fajardo, J. ; Herranz, M. A. ; Gómez, J. I. ; García, R. M. ; Espina, M. J. ; Garnacho, J. ; Ortiz, C. ; Palomar, M. ; Montero J, J. ; Cisneros, C. ; Sandiumenje, A. ; Sánchez, M. ; Álvarez, M. ; López, V. ; Julve, R. ; Solé, J. ; Valerón, M. ; Blasco, M. A. ; Borrás, S. ; Maraví, E. ; Urtasun, J. M. ; Sánchez-Díaz, C. ; Tamayo, L. M. ; Blanco, J. ; Galdós, P. ; Barredo, F. ; Rodríguez, A. ; Castaño, J. / Risk factors for candidaemia in critically ill patients: A prospective surveillance study. In: Mycoses. 2007 ; Vol. 50, No. 4. pp. 302-310.

@article{fe2567834e274afbb36c37e68ce47be5,

title = "Risk factors for candidaemia in critically ill patients: A prospective surveillance study",

abstract = "Candidaemia is frequently a life-threatening complication in patients admitted to the intensive care unit (ICU). To assess the risk factors for candidaemia in critically ill patients with prolonged ICU stay, a total of 1765 adult patients admitted for at least 7 days to 73 medical-surgical ICUs of 70 tertiary care hospitals in Spain participated in a prospective cohort study. Candidaemia was defined as recovery of Candida spp. from blood culture. Sixty-eight episodes of candidaemia occurred in 63 patients, representing 35.7 episodes per 1000 ICU patients admitted, with an incidence rate of 1.5 episodes per 1000 days of ICU stay. Causative fungi were C. albicans in 57.1% of cases and non-albicansCandida spp. in 42.9%. In the multivariate analysis, independent factors significantly associated with candidaemia were Candida colonisation (OR = 4.12, 95% CI: 1.82-9.33), total parenteral nutrition (OR = 3.89, 95% CI: 1.73-8.78), elective surgery (OR = 2.75, 95% CI: 1.17-6.45) and haemofiltration procedures (OR = 1.96, 95% CI: 1.06-3.62). In the ICU setting in Spain and in patients who have stayed in units for >7 days, more than half of cases of candidaemia were caused by C. albicans. Risk factors for candidaemia identified included Candida colonisation, elective surgery, total parenteral nutrition and haemodialysis. {\textcopyright} 2007 The Authors.",

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author = "Ricard Jord{\`a}-Marcos and Francisco {\'A}lvarez-Lerma and Maite Jurado and Mercedes Palomar and Juan Nolla-Salas and Le{\'o}n, {Mar{\'i}a A.} and Crist{\'o}bal Le{\'o}n and J. Nolla and F. {\'A}lvarez-Lerma and M. Salvad{\'o} and N. Carrasco and A. Bueno and F. Bobillo and P. Ucio and Le{\'o}n, {M. A.} and M. Nolla and D{\'i}az, {R. A.} and Iruretagoyena, {J. R.} and K. Esnaola and I. Andetxaga and A. Blanco and F. Taboada and R. Fern{\'a}ndez and M. Nieto and R. Diego and F. Ortu{\~n}o and P. Marcos and E. Mesalles and A. Mart{\'i}nez and M. Fern{\'a}ndez and F. Jaime and H. Sancho and N. Izquierdo and M. Ulibarrena and F. Labayen and F. Barcenilla and Gil, {M. J.} and B. Balsera and R. Jord{\'a} and Maite Jurado and J. P{\'e}rez and E. Zavala and A. Alc{\'o}n and N. Fabregues and {De La Torre}, {M. V.} and Estecha, {M. A.} and A. Soler and M. Bod{\'i} and D. Castander and A. Mend{\'i}a and J. Artaetxebarr{\'i}a and C. Reviejo and M. S{\'a}nchez and A. Casamitjana and C. P{\'e}rez and L{\'o}pez, {M. J.} and E. Robles and Y. Insausti and Tihistsa, {J. A.} and C. Garc{\'i}a and Rubio, {J. M.} and R. Oltra and O. Rodr{\'i}guez and P. Olaechea and {De Cel{\'i}s}, R. and Soto, {J. M.} and J. Pomares and J. Luna and G. Masdeu and R. Sierra and A. Gordillo and R. Rodr{\'i}guez and J. Fajardo and Herranz, {M. A.} and G{\'o}mez, {J. I.} and Garc{\'i}a, {R. M.} and Espina, {M. J.} and J. Garnacho and C. Ortiz and M. Palomar and {Montero J}, J. and C. Cisneros and A. Sandiumenje and M. S{\'a}nchez and M. {\'A}lvarez and V. L{\'o}pez and R. Julve and J. Sol{\'e} and M. Valer{\'o}n and Blasco, {M. A.} and S. Borr{\'a}s and E. Marav{\'i} and Urtasun, {J. M.} and C. S{\'a}nchez-D{\'i}az and Tamayo, {L. M.} and J. Blanco and P. Gald{\'o}s and F. Barredo and A. Rodr{\'i}guez and J. Casta{\~n}o",

year = "2007",

month = jul,

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doi = "10.1111/j.1439-0507.2007.01366.x",

language = "English",

volume = "50",

pages = "302--310",

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Jordà-Marcos, R, Álvarez-Lerma, F, Jurado, M, Palomar, M, Nolla-Salas, J, León, MA, León, C, Nolla, J, Álvarez-Lerma, F, Salvadó, M, Carrasco, N, Bueno, A, Bobillo, F, Ucio, P, León, MA, Nolla, M, Díaz, RA, Iruretagoyena, JR, Esnaola, K, Andetxaga, I, Blanco, A, Taboada, F, Fernández, R, Nieto, M, Diego, R, Ortuño, F, Marcos, P, Mesalles, E, Martínez, A, Fernández, M, Jaime, F, Sancho, H, Izquierdo, N, Ulibarrena, M, Labayen, F, Barcenilla, F, Gil, MJ, Balsera, B, Jordá, R, Jurado, M, Pérez, J, Zavala, E, Alcón, A, Fabregues, N, De La Torre, MV, Estecha, MA, Soler, A, Bodí, M, Castander, D, Mendía, A, Artaetxebarría, J, Reviejo, C, Sánchez, M, Casamitjana, A, Pérez, C, López, MJ, Robles, E, Insausti, Y, Tihistsa, JA, García, C, Rubio, JM, Oltra, R, Rodríguez, O, Olaechea, P, De Celís, R, Soto, JM, Pomares, J, Luna, J, Masdeu, G, Sierra, R, Gordillo, A, Rodríguez, R, Fajardo, J, Herranz, MA, Gómez, JI, García, RM, Espina, MJ, Garnacho, J, Ortiz, C, Palomar, M, Montero J, J, Cisneros, C, Sandiumenje, A, Sánchez, M, Álvarez, M, López, V, Julve, R, Solé, J, Valerón, M, Blasco, MA, Borrás, S, Maraví, E, Urtasun, JM, Sánchez-Díaz, C, Tamayo, LM, Blanco, J, Galdós, P, Barredo, F, Rodríguez, A & Castaño, J 2007, 'Risk factors for candidaemia in critically ill patients: A prospective surveillance study', Mycoses, vol. 50, no. 4, pp. 302-310. https://doi.org/10.1111/j.1439-0507.2007.01366.x

Risk factors for candidaemia in critically ill patients: A prospective surveillance study. / Jordà-Marcos, Ricard; Álvarez-Lerma, Francisco; Jurado, Maite; Palomar, Mercedes; Nolla-Salas, Juan; León, María A.; León, Cristóbal; Nolla, J.; Álvarez-Lerma, F.; Salvadó, M.; Carrasco, N.; Bueno, A.; Bobillo, F.; Ucio, P.; León, M. A.; Nolla, M.; Díaz, R. A.; Iruretagoyena, J. R.; Esnaola, K.; Andetxaga, I.; Blanco, A.; Taboada, F.; Fernández, R.; Nieto, M.; Diego, R.; Ortuño, F.; Marcos, P.; Mesalles, E.; Martínez, A.; Fernández, M.; Jaime, F.; Sancho, H.; Izquierdo, N.; Ulibarrena, M.; Labayen, F.; Barcenilla, F.; Gil, M. J.; Balsera, B.; Jordá, R.; Jurado, Maite; Pérez, J.; Zavala, E.; Alcón, A.; Fabregues, N.; De La Torre, M. V.; Estecha, M. A.; Soler, A.; Bodí, M.; Castander, D.; Mendía, A.; Artaetxebarría, J.; Reviejo, C.; Sánchez, M.; Casamitjana, A.; Pérez, C.; López, M. J.; Robles, E.; Insausti, Y.; Tihistsa, J. A.; García, C.; Rubio, J. M.; Oltra, R.; Rodríguez, O.; Olaechea, P.; De Celís, R.; Soto, J. M.; Pomares, J.; Luna, J.; Masdeu, G.; Sierra, R.; Gordillo, A.; Rodríguez, R.; Fajardo, J.; Herranz, M. A.; Gómez, J. I.; García, R. M.; Espina, M. J.; Garnacho, J.; Ortiz, C.; Palomar, M.; Montero J, J.; Cisneros, C.; Sandiumenje, A.; Sánchez, M.; Álvarez, M.; López, V.; Julve, R.; Solé, J.; Valerón, M.; Blasco, M. A.; Borrás, S.; Maraví, E.; Urtasun, J. M.; Sánchez-Díaz, C.; Tamayo, L. M.; Blanco, J.; Galdós, P.; Barredo, F.; Rodríguez, A.; Castaño, J.

In: Mycoses, Vol. 50, No. 4, 01.07.2007, p. 302-310.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Risk factors for candidaemia in critically ill patients: A prospective surveillance study

AU - Jordà-Marcos, Ricard

AU - Álvarez-Lerma, Francisco

AU - Jurado, Maite

AU - Palomar, Mercedes

AU - Nolla-Salas, Juan

AU - León, María A.

AU - León, Cristóbal

AU - Nolla, J.

AU - Álvarez-Lerma, F.

AU - Salvadó, M.

AU - Carrasco, N.

AU - Bueno, A.

AU - Bobillo, F.

AU - Ucio, P.

AU - León, M. A.

AU - Nolla, M.

AU - Díaz, R. A.

AU - Iruretagoyena, J. R.

AU - Esnaola, K.

AU - Andetxaga, I.

AU - Blanco, A.

AU - Taboada, F.

AU - Fernández, R.

AU - Nieto, M.

AU - Diego, R.

AU - Ortuño, F.

AU - Marcos, P.

AU - Mesalles, E.

AU - Martínez, A.

AU - Fernández, M.

AU - Jaime, F.

AU - Sancho, H.

AU - Izquierdo, N.

AU - Ulibarrena, M.

AU - Labayen, F.

AU - Barcenilla, F.

AU - Gil, M. J.

AU - Balsera, B.

AU - Jordá, R.

AU - Jurado, Maite

AU - Pérez, J.

AU - Zavala, E.

AU - Alcón, A.

AU - Fabregues, N.

AU - De La Torre, M. V.

AU - Estecha, M. A.

AU - Soler, A.

AU - Bodí, M.

AU - Castander, D.

AU - Mendía, A.

AU - Artaetxebarría, J.

AU - Reviejo, C.

AU - Sánchez, M.

AU - Casamitjana, A.

AU - Pérez, C.

AU - López, M. J.

AU - Robles, E.

AU - Insausti, Y.

AU - Tihistsa, J. A.

AU - García, C.

AU - Rubio, J. M.

AU - Oltra, R.

AU - Rodríguez, O.

AU - Olaechea, P.

AU - De Celís, R.

AU - Soto, J. M.

AU - Pomares, J.

AU - Luna, J.

AU - Masdeu, G.

AU - Sierra, R.

AU - Gordillo, A.

AU - Rodríguez, R.

AU - Fajardo, J.

AU - Herranz, M. A.

AU - Gómez, J. I.

AU - García, R. M.

AU - Espina, M. J.

AU - Garnacho, J.

AU - Ortiz, C.

AU - Palomar, M.

AU - Montero J, J.

AU - Cisneros, C.

AU - Sandiumenje, A.

AU - Sánchez, M.

AU - Álvarez, M.

AU - López, V.

AU - Julve, R.

AU - Solé, J.

AU - Valerón, M.

AU - Blasco, M. A.

AU - Borrás, S.

AU - Maraví, E.

AU - Urtasun, J. M.

AU - Sánchez-Díaz, C.

AU - Tamayo, L. M.

AU - Blanco, J.

AU - Galdós, P.

AU - Barredo, F.

AU - Rodríguez, A.

AU - Castaño, J.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Candidaemia is frequently a life-threatening complication in patients admitted to the intensive care unit (ICU). To assess the risk factors for candidaemia in critically ill patients with prolonged ICU stay, a total of 1765 adult patients admitted for at least 7 days to 73 medical-surgical ICUs of 70 tertiary care hospitals in Spain participated in a prospective cohort study. Candidaemia was defined as recovery of Candida spp. from blood culture. Sixty-eight episodes of candidaemia occurred in 63 patients, representing 35.7 episodes per 1000 ICU patients admitted, with an incidence rate of 1.5 episodes per 1000 days of ICU stay. Causative fungi were C. albicans in 57.1% of cases and non-albicansCandida spp. in 42.9%. In the multivariate analysis, independent factors significantly associated with candidaemia were Candida colonisation (OR = 4.12, 95% CI: 1.82-9.33), total parenteral nutrition (OR = 3.89, 95% CI: 1.73-8.78), elective surgery (OR = 2.75, 95% CI: 1.17-6.45) and haemofiltration procedures (OR = 1.96, 95% CI: 1.06-3.62). In the ICU setting in Spain and in patients who have stayed in units for >7 days, more than half of cases of candidaemia were caused by C. albicans. Risk factors for candidaemia identified included Candida colonisation, elective surgery, total parenteral nutrition and haemodialysis. © 2007 The Authors.

AB - Candidaemia is frequently a life-threatening complication in patients admitted to the intensive care unit (ICU). To assess the risk factors for candidaemia in critically ill patients with prolonged ICU stay, a total of 1765 adult patients admitted for at least 7 days to 73 medical-surgical ICUs of 70 tertiary care hospitals in Spain participated in a prospective cohort study. Candidaemia was defined as recovery of Candida spp. from blood culture. Sixty-eight episodes of candidaemia occurred in 63 patients, representing 35.7 episodes per 1000 ICU patients admitted, with an incidence rate of 1.5 episodes per 1000 days of ICU stay. Causative fungi were C. albicans in 57.1% of cases and non-albicansCandida spp. in 42.9%. In the multivariate analysis, independent factors significantly associated with candidaemia were Candida colonisation (OR = 4.12, 95% CI: 1.82-9.33), total parenteral nutrition (OR = 3.89, 95% CI: 1.73-8.78), elective surgery (OR = 2.75, 95% CI: 1.17-6.45) and haemofiltration procedures (OR = 1.96, 95% CI: 1.06-3.62). In the ICU setting in Spain and in patients who have stayed in units for >7 days, more than half of cases of candidaemia were caused by C. albicans. Risk factors for candidaemia identified included Candida colonisation, elective surgery, total parenteral nutrition and haemodialysis. © 2007 The Authors.

KW - Candida colonisation

KW - Candidaemia

KW - Critically ill patients

KW - Intensive care unit

KW - Risk factors

U2 - 10.1111/j.1439-0507.2007.01366.x

DO - 10.1111/j.1439-0507.2007.01366.x

M3 - Article

VL - 50

SP - 302

EP - 310

IS - 4

ER -

Risk factors for candidaemia in critically ill patients: A prospective surveillance study

Abstract

Keywords

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