TY - JOUR
T1 - Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life
AU - Pérez-Yarza, Eduardo G.
AU - Moreno-Galdó, Antonio
AU - Ramilo, Octavio
AU - Rubí, Teresa
AU - Escribano, Amparo
AU - Torres, Antonio
AU - Sardón, Olaia
AU - Oliva, Concepción
AU - Pérez, Guadalupe
AU - Cortell, Isidoro
AU - Rovira-Amigo, Sandra
AU - Pastor-Vivero, Maria D.
AU - Pérez-Frías, Javier
AU - Velasco, Valle
AU - Torres-Borrego, Javier
AU - Figuerola, Joan
AU - Barrio, Maria Isabel
AU - García-Hernández, Gloria
AU - Mejías, Asunción
AU - Aldasoro, A.
AU - Corcuera, P.
AU - Korta, J.
AU - Bosch, J.
AU - Morera, G.
AU - Mumany, M.
AU - Batlles-Garrido, J.
AU - González-Giménez, Y.
AU - Romero, T.
AU - Morata, J.
AU - Navarro-Merino, M.
AU - Sanchez-Solis, M.
AU - Mondejar Lopez, P.
AU - Gómez-Acebo, Francisca
PY - 2015/12/1
Y1 - 2015/12/1
N2 - © 2015 John Wiley & Sons A/S. Background: Airway diseases are highly prevalent in infants and cause significant morbidity. We aimed to determine the incidence and risk factors for respiratory morbidity in a Spanish cohort of moderate-to-late preterm (MLP) infants prospectively followed during their first year of life. Methods: SAREPREM is a multicenter, prospective, longitudinal study. Preterm infants born at 32-35 weeks of gestation with no comorbidities were enrolled within 2 weeks of life and followed at 2-4 weeks, 6, and 12 months of age. Multivariate mixed-models were performed to identify independent risk factors associated with (i) development of bronchiolitis, (ii) recurrent wheezing, or (iii) related hospital admissions. Results: Overall, 977 preterm infants were included, and 766 (78.4%) completed follow-up. Of those, 365 (47.7%) developed bronchiolitis during the first year, 144 (18.8%) recurrent wheezing, and 48 (6.3%) were hospitalized. While low birthweight, day care attendance (DCA) and school-age siblings were significantly and independently associated with both the development of bronchiolitis and recurrent wheezing, lower maternal age increased the risk for bronchiolitis and respiratory-related hospitalizations. Lastly, mechanical ventilation was associated with a higher risk of bronchiolitis and history of asthma in any parent increased the likelihood of developing recurrent wheezing. Conclusions: In this study, several non-modifiable parameters (family history of asthma, low birthweight, need for mechanical ventilation) and modifiable parameters (young maternal age, DCA, or exposure to school-age siblings) were identified as significant risk factors for the development of bronchiolitis and recurrent wheezing during the first year of life in MLP infants.
AB - © 2015 John Wiley & Sons A/S. Background: Airway diseases are highly prevalent in infants and cause significant morbidity. We aimed to determine the incidence and risk factors for respiratory morbidity in a Spanish cohort of moderate-to-late preterm (MLP) infants prospectively followed during their first year of life. Methods: SAREPREM is a multicenter, prospective, longitudinal study. Preterm infants born at 32-35 weeks of gestation with no comorbidities were enrolled within 2 weeks of life and followed at 2-4 weeks, 6, and 12 months of age. Multivariate mixed-models were performed to identify independent risk factors associated with (i) development of bronchiolitis, (ii) recurrent wheezing, or (iii) related hospital admissions. Results: Overall, 977 preterm infants were included, and 766 (78.4%) completed follow-up. Of those, 365 (47.7%) developed bronchiolitis during the first year, 144 (18.8%) recurrent wheezing, and 48 (6.3%) were hospitalized. While low birthweight, day care attendance (DCA) and school-age siblings were significantly and independently associated with both the development of bronchiolitis and recurrent wheezing, lower maternal age increased the risk for bronchiolitis and respiratory-related hospitalizations. Lastly, mechanical ventilation was associated with a higher risk of bronchiolitis and history of asthma in any parent increased the likelihood of developing recurrent wheezing. Conclusions: In this study, several non-modifiable parameters (family history of asthma, low birthweight, need for mechanical ventilation) and modifiable parameters (young maternal age, DCA, or exposure to school-age siblings) were identified as significant risk factors for the development of bronchiolitis and recurrent wheezing during the first year of life in MLP infants.
KW - Bronchiolitis
KW - Bronchitis
KW - Premature birth
KW - Risk factors
KW - Wheezing
U2 - 10.1111/pai.12414
DO - 10.1111/pai.12414
M3 - Article
SN - 0905-6157
VL - 26
SP - 797
EP - 804
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 8
ER -