Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: Long-term outcome of the LPA 99 multicenter study by the PETHEMA Group

Miguel A. Sanz, Pau Montesinos, Edo Vellenga, Consuelo Rayón, Javier De La Serna, Ricardo Parody, Juan M. Bergua, Angel León, Silvia Negri, Marcos González, Concha Rivas, Jordi Esteve, Gustavo Milone, José D. González, Elena Amutio, Salut Brunet, J. García-Laraña, Dolors Colomer, María J. Calasanz, Carmen ChillónEva Barragán, Pascual Bolufer, Bob Lowenberg

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106 Citations (Scopus)

Abstract

A previous report of the Programa de Estudio y Tratamiento de las Hemopatfas Malignas (PETHEMA) Group showed that a risk-adapted strategy combining all-trans retinoic acid (ATRA) and anthracycline monochemotherapy for induction and consolidation in newly diagnosed acute promyelocytic leukemia results in an improved outcome. Here we analyze treatment outcome of an enlarged series of patients who have been followed up for a median of 65 months. From November 1999 through July 2005 (LPA99 trial), 560 patients received induction therapy with ATRA plus idarubicin. Patients achieving complete remission received 3 courses of consolidation followed by maintenance with ATRA and low-dose chemotherapy. The 5-year cumulative incidence of relapse and disease-free survival were 11% and 84%, respectively. These results compare favorably with those obtained in the previous LPA96 study (P=.019 and P=.04, respectively). This updated analysis confirms the high antileukemic efficacy, low toxicity, and high degree of compliance of a riskadapted strategy combining ATRA and anthracycline monochemotherapy for consolidation therapy.
Original languageEnglish
Pages (from-to)3130-3134
JournalBlood
Volume112
Issue number8
DOIs
Publication statusPublished - 15 Oct 2008

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