Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases

Michela De Lucia, Mar Bardagi, Elisabetta Fabbri, Diana Ferreira, Lluis Ferrer, Fabia Scarampella, Giordana Zanna, Alessandra Fondati

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Abstract

© 2016 ESVD and ACVD Background: Rifampicin has received increased interest in veterinary dermatology because of its activity against multidrug-resistant meticillin-resistant staphylococci (MRS). There is limited knowledge about the efficacy and safety of rifampicin in dogs. Hypothesis/Objective: To provide information on response to treatment and adverse effects in dogs treated with rifampicin for multidrug-resistant MRS pyoderma. Animals: Thirty two dogs treated with rifampicin for rifampicin-susceptible multidrug-resistant MRS pyoderma. Methods: Retrospective review of medical records, including alanine aminotransferase (ALT) and alkaline phosphatase (ALP) serum activity levels and total bilirubin concentrations, obtained before and throughout the treatment, was performed. Results: Oral rifampicin as sole systemic antimicrobial therapy (median dose 5 mg/kg twice daily) was effective in 71.88% of cases. Topical antimicrobials were used in most cases. Median duration of rifampicin treatment was five weeks for superficial pyoderma and four weeks for deep pyoderma. Gastrointestinal signs were reported in 15% of treated dogs. Statistically significant increases of ALT (P = 0.045) and ALP (P = 0.0002) values after 3–4 weeks of treatment was observed. The median increase was equal to 0.3 and ×1.5 the upper limit of the reference ranges for ALT and ALP, respectively. Conclusions/Clinical importance: Oral rifampicin combined with topical antimicrobials can be considered an effective therapeutic option for canine superficial and deep pyoderma caused by rifampicin-susceptible multidrug-resistant MRS. Liver enzyme induction might be the most important cause of ALT and ALP increase associated with rifampicin therapy in dogs.
Original languageEnglish
Pages (from-to)171-e36
JournalVeterinary Dermatology
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

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    De Lucia, M., Bardagi, M., Fabbri, E., Ferreira, D., Ferrer, L., Scarampella, F., Zanna, G., & Fondati, A. (2017). Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases. Veterinary Dermatology, 28(2), 171-e36. https://doi.org/10.1111/vde.12404