A new efficient multicatalytic process involving a single catalyst to promote tandem hydroformylation/arylation reactions is disclosed. The effect of the rhodium ligand was evaluated and the rhodium/triphenylphosphine catalytic system was selected to apply the methodology to different olefins and boronic acids. High yields (up to 89%) and good to excellent isomer ratios (up to 98:2) were achieved using aryl olefins as starting materials. This new methodology allows the preparation of secondary alcohols, from simple olefins, and paves the way for the synthesis of high-value products, namely vinylindole and anethole derivatives. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- multicatalytic process
- tandem reactions
Almeida, A. R., Dias, R. D., Monteiro, C. J. P., Abreu, A. R., Gois, P. M. P., Bayon, J. C., & Pereira, M. M. (2014). Rhodium-catalysed tandem hydroformylation/arylation reaction with boronic acids. Advanced Synthesis and Catalysis, 356(6), 1223-1228. https://doi.org/10.1002/adsc.201300968