Rhabdomyosarcomas developing in association with mediastinal germ cell tumours

Carmelo Caballero, Silvia Gomez, Xavier Matias-Guiu, Jaime Prat

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22 Citations (Scopus)


Two mediastinal rhabdomyosarcomas that arose in association with germ cell tumours are reported. One presented as a small component of a mixed germ cell tumour with yolk sac and immature teratomatous elements. The other appeared as a large mass 4 months after diagnosis of a yolk sac carcinoma that had been treated with chemotherapy. The first patient was alive and free of disease 7 years later, whereas the second died of tumour 3 months post-operatively. The proportion of rhabdomyosarcoma within the germ cell tumours appears to have influenced the prognosis of these patients. This observation emphasizes the necessity of performing a thorough search for sarcomatous elements and quantifying their relative proportion in germ cell tumours of the mediastinum. © 1992 Springer-Verlag.
Original languageEnglish
Pages (from-to)539-543
JournalVirchows Archiv - A Pathological Anatomy and Histopathology
Issue number6
Publication statusPublished - 1 Nov 1992


  • Germ cell tumour
  • Mediastinum
  • Rhabdomyosarcoma


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