TY - JOUR
T1 - RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors
AU - Domingo-Espín, Joan
AU - Petegnief, Valérie
AU - de Vera, Núria
AU - Conchillo-Solé, Oscar
AU - Saccardo, Paolo
AU - Unzueta, Ugutz
AU - Vazquez, Esther
AU - Cedano, Juan
AU - Negro, Luciana
AU - Daura, Xavier
AU - Peluffo, Hugo
AU - Planas, Anna M.
AU - Villaverde, Antonio
AU - Ferrer-Miralles, Neus
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Integrin-binding, Arg-Gly-Asp (RGD)-containing peptides are the most widely used agents to deliver drugs, nanoparticles, and imaging agents. Although in nature, several protein-mediated signal transduction events depend on RGD motifs, the potential of RGD-empowered materials in triggering undesired cell-signaling cascades has been neglected. Using an RGD-functionalized protein nanoparticle, we show here that the RGD motif acts as a powerful trophic factor, supporting extracellular signal-regulated kinase 1/2 (ERK1/2)-linked cell proliferation and partial differentiation of PC12 cells, a neuronlike model. From the Clinical Editor: This work focuses on RGD peptides, which are among the most commonly used tags for targeted drug delivery. They also promote protoneurite formation and expression of neuronal markers (MAP2) in model PC12 cells, which is an unexpected but relevant event in the functionalization of drugs and their nanocarriers. © 2012 Elsevier Inc.
AB - Integrin-binding, Arg-Gly-Asp (RGD)-containing peptides are the most widely used agents to deliver drugs, nanoparticles, and imaging agents. Although in nature, several protein-mediated signal transduction events depend on RGD motifs, the potential of RGD-empowered materials in triggering undesired cell-signaling cascades has been neglected. Using an RGD-functionalized protein nanoparticle, we show here that the RGD motif acts as a powerful trophic factor, supporting extracellular signal-regulated kinase 1/2 (ERK1/2)-linked cell proliferation and partial differentiation of PC12 cells, a neuronlike model. From the Clinical Editor: This work focuses on RGD peptides, which are among the most commonly used tags for targeted drug delivery. They also promote protoneurite formation and expression of neuronal markers (MAP2) in model PC12 cells, which is an unexpected but relevant event in the functionalization of drugs and their nanocarriers. © 2012 Elsevier Inc.
KW - Biomaterials
KW - Integrins
KW - Neurons
KW - Protein nanoparticles
KW - RGD
U2 - https://doi.org/10.1016/j.nano.2012.06.005
DO - https://doi.org/10.1016/j.nano.2012.06.005
M3 - Article
VL - 8
SP - 1263
EP - 1266
ER -