Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines

Javier García-Tojal, Rubén Gil-García, Víctor Ivo Fouz, Gotzon Madariaga, Luis Lezama, María S. Galletero, Joaquín Borrás, Friederike I. Nollmann, Carlos García-Girón, Raquel Alcaraz, Mónica Cavia-Saiz, Pilar Muñiz, Òscar Palacios, Katia G. Samper, Teófilo Rojo

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7 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC = pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu(PTSC*)(ONO2)}2] derivative (2, HPTSC* = pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.
Original languageEnglish
Pages (from-to)69-79
JournalJournal of Inorganic Biochemistry
Volume180
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Colon carcinoma
  • Copper
  • Molecular magnetism
  • Thiosemicarbazone

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    García-Tojal, J., Gil-García, R., Fouz, V. I., Madariaga, G., Lezama, L., Galletero, M. S., Borrás, J., Nollmann, F. I., García-Girón, C., Alcaraz, R., Cavia-Saiz, M., Muñiz, P., Palacios, Ò., Samper, K. G., & Rojo, T. (2018). Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines. Journal of Inorganic Biochemistry, 180, 69-79. https://doi.org/10.1016/j.jinorgbio.2017.12.005