Retrosynthetic Analysis Applied to Clip-off Chemistry : Synthesis of Four Rh(II)-Based Complexes as Proof-of-Concept

Anna Broto-Ribas, Sara Ruiz Relaño, Jorge Albalad, Yunhui Yang, Felipe Gándara, Judith Juanhuix, Inhar Imaz, Daniel Maspoch Comamala

    Research output: Contribution to journalArticleResearchpeer-review

    1 Citation (Scopus)

    Abstract

    Clip-off Chemistry is a synthetic strategy that our group previously developed to obtain new molecules and materials through selective cleavage of bonds. Herein, we report recent work to expand Clip-off Chemistry by introducing into it a retrosynthetic analysis step that, based on virtual extension of the products through cleavable bonds, enables one to define the required precursor materials. As proof-of-concept, we have validated our new approach by synthesising and characterising four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.In Clip-off Chemistry, a retrosynthetic analysis step based on virtual extension of the products through cleavable bonds enables defining the required precursor materials. As proof-of-concept, this new approach is used to synthesize four aldehyde-functionalised Rh(II)-based complexes: a homoleptic cluster; a cis-disubstituted paddlewheel cluster; a macrocycle; and a crown.+image
    Original languageEnglish
    Article numbere202310354
    Pages (from-to)e202310354
    Number of pages8
    JournalAngewandte Chemie - International Edition
    Volume62
    Issue number48
    DOIs
    Publication statusPublished - 27 Nov 2023

    Keywords

    • Bond Breaking
    • Clip-off Chemistry
    • Disassembly
    • Metal-Organic Polyhedra
    • Retrosynthetic Analysis

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