Results of compassionate therapy with intrathecal depot liposomal cytarabine in acute myeloid leukemia meningeosis

Juan Manuel Sancho, Guillermo Deben, Anne Parker, José Luis Piñana, Simon Bolam, Eva Sánchez-García, Eugenio Giménez, Teresa Pascual, Pascual Fernández-Abellán, Luis Palomera, Josep Maria Ribera

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Intrathecal (IT) depot liposomal cytarabine is useful in solid tumors or lymphomatous meningitis, but has scarcely been used in central nervous system (CNS) involvement in acute leukemia. We report the results of compassionate therapy with IT depot liposomal cytarabine in 10 patients with acute myeloid leukemia with CNS involvement. Five of 6 cases receiving this drug as the only IT therapy and the remaining 4 receiving it as adjuvant therapy to other CNS-directed therapies showed clearance of cerebrospinal fluid blast cells, with sustained response in 5 and mild side effects. Systemic therapy was given concomitantly in all cases, with high-dose cytarabine in 6. Clinical trials should establish the role of IT liposomal cytarabine in leukemic meningitis. © 2007 The Japanese Society of Hematology.
Original languageEnglish
Pages (from-to)33-36
JournalInternational Journal of Hematology
Volume86
Issue number1
DOIs
Publication statusPublished - 1 Jul 2007

Keywords

  • Acute leukemia
  • CNS, meningeosis
  • Intrathecal depot liposomal cytarabine
  • Treatment

Fingerprint

Dive into the research topics of 'Results of compassionate therapy with intrathecal depot liposomal cytarabine in acute myeloid leukemia meningeosis'. Together they form a unique fingerprint.

Cite this