Restriction to a limited set of eeg-target variables may lead to misinterpretation of pharmaco-eeg results

Peter Anderer, Manuel J. Barbanoj, Bernd Saletu, Heribert V. Semlitsch

    Research output: Contribution to journalArticleResearchpeer-review

    19 Citations (Scopus)

    Abstract

    The number and types of target variables quantified from the spectrally analyzed EEG used in topographic pharmaco-EEG studies are still being discussed. Drug-induced changes of target variables obtained in the alpha frequency band - four absolute and four relative powers as well as three frequency measures - were utilized to assess the effects of xantinolnicotinate in demented patients using a parallel group design and the effects of buspirone in a double-blind, placebo-controlled crossover design. We conclude that for the proper evaluation of the different drug effects on the alpha activity, all these target variables should be considered. Descriptive p values of multiple comparisons within the framework of descriptive data analyses are important tools in interpreting drug effects. © 1993 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)112-116
    JournalNeuropsychobiology
    Volume27
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1993

    Keywords

    • Buspirone
    • Descriptive data analysis
    • EEG brain mapping
    • Human psychopharmacology
    • Pharmaco-EEG
    • Spectral analysis
    • Target variables
    • Xantinolnicotinate

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