Restraint stress induced changes in rat liver and serum metallothionein and in Zn metabolism

Juan Hidalgo*, A. Armario, R. Flos, J. S. Garvey

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    23 Citations (Scopus)


    24 h of a psychogenic stress (restraint) caused a strong increase of liver metallothionein (MT) levels. 3 h of stress were sufficient to induce an increase in liver MT, measured 21 h later, but the increase was much lower than in continuously restrained rats. Stress induction of liver MT was not due to food deprivation, since rats deprived for 24 h showed lower MT levels than stressed ones. Zn on MT presented the same qualitative but not quantitative pattern of response as MT protein. Liver cytosolic Zn was increased by restraint in spite of their being no decrease in serum Zn. Any treatment altered serum MT. Liver and serum MT were not correlated. The present results demonstrate that basically psychogenic stresses increased liver but not serum MT levels. No positive evidence for a relationship between corticosterone secretion and MT induction was found. © 1986 Birkhäuser Verlag Basel.
    Original languageEnglish
    Pages (from-to)1006-1010
    Publication statusPublished - 1 Sep 1986


    • Metallothionein
    • copper
    • pituitary-adrenal
    • restraint stress
    • zinc


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