Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura

Cèlia Sintas, Jèssica Fernández-Morales, Marta Vila-Pueyo, Bernat Narberhaus, Concepció Arenas, Patricia Pozo-Rosich, Alfons Macaya, Bru Cormand

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17 Citations (Scopus)

Abstract

© International Headache Society 2014. Background: Migraine is a common disabling condition that affects approximately 15% of the population. Several genomewide association studies have attempted to identify susceptibility variants involved in migraine, reporting several candidate loci for the disorder. Methods: In order to replicate findings from previous genome-wide association studies, a case-control association study was performed. Twelve single nucleotide polymorphisms were genotyped in a Spanish sample of 512 migraine with aura patients and 535 migraine-free controls. Results: Nominal associations were found for single nucleotide polymorphisms rs2651899 (within the PRDM16 gene), rs10166942 (near TRPM8), rs12134493 (close to TSPAN2) and rs10504861 (near MMP16) in our migraine with aura sample. Conclusions: Our study provides suggestive replication, in a Spanish migraine with aura sample, of four genome-wide association study findings previously reported in common migraine. However, larger sample sets should be explored to confirm our results.
Original languageEnglish
Pages (from-to)776-782
JournalCephalalgia
Volume35
Issue number9
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • association study
  • Migraine with aura
  • MMP16
  • PRDM16
  • TRPM8
  • TSPAN2

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