RENEB/EURADOS field exercise 2019: robust dose estimation under outdoor conditions based on the dicentric chromosome assay

David Endesfelder, Ursula Oestreicher, Ulrike Kulka, Elizabeth A Ainsbury, Jayne Moquet, Stephen Barnard, Eric Gregoire, Juan S Martinez, François Trompier, Yoann Ristic, Clemens Woda, Lovisa Waldner, Christina Beinke, Anne Vral, Joan-Francesc Barquinero, Alfredo Hernandez, Sylwester Sommer, Katalin Lumniczky, Rita Hargitai, Alegría MontoroMirta Milic, Octávia Monteiro Gil, Marco Valente, Laure Bobyk, Olga Sevriukova, Laure Sabatier, María Jesús Prieto, Mercedes Moreno Domene, Antonella Testa, Clarice Patrono, Georgia Terzoudi, Sotiria Triantopoulou, Rositsa Histova, Andrzej Wojcik

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13 Citations (Web of Science)


Purpose Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq Ir-192-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses. Results The DCA results were homogeneous between participants and matched well with the reference doses (>= 95% of estimates within +/- 0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates. Conclusions The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalInternational Journal of Radiation Biology
Issue number9
Early online date7 Jul 2021
Publication statusPublished - 2 Sept 2021


  • biological dosimetry
  • Dicentric chromosome
  • inter-laboratory comparison


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