Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease

José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, D. Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.
Original languageEnglish
Pages (from-to)2564-2566
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

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