Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease

José Moltó; Fredzzia Graterol; Cristina Miranda; Saye Khoo; D. Ioana Bancu; Alieu Amara; Anna Bonjoch; Bonaventura Clotet

doi:10.1128/AAC.03131-15

Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease

José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, D. Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.

Original language	English
Pages (from-to)	2564-2566
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1128/AAC.03131-15
Publication status	Published - 1 Apr 2016

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title = "Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease",

abstract = "Copyright {\textcopyright} 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.",

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Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease. / Moltó, José; Graterol, Fredzzia; Miranda, Cristina; Khoo, Saye; Bancu, D. Ioana; Amara, Alieu; Bonjoch, Anna; Clotet, Bonaventura.

In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 4, 01.04.2016, p. 2564-2566.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Moltó, José

AU - Graterol, Fredzzia

AU - Miranda, Cristina

AU - Khoo, Saye

AU - Bancu, D. Ioana

AU - Amara, Alieu

AU - Bonjoch, Anna

AU - Clotet, Bonaventura

PY - 2016/4/1

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N2 - Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.

AB - Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.

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