Release of neurotransmitters from rat brain nerve terminals after chronic ethanol ingestion: Differential effects in cortex and hippocampus

Josefa Sabrià, Dámaso Torres, Manel Pastó, Josep M. Peralba, Abdellah Allali-Hassani, Xavier Parés

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

To gain a better insight into the alterations of brain function after chronic ethanol, we measured the release of various neurotransmitters from nerve terminals of cortex and hippocampus isolated from rats chronically fed with ethanol. The K+-evoked release of [3H]acetylcholine (ACh), [3H]dopamine (DA), [3H]glutamate (Glu) and [ 3H]noradrenaline (NA) was determined in superfused synaptosomes of brain cortex and hippocampus from rats exposed to the Lieber-DeCarli alcohol liquid diet for 5 weeks. In cortical synaptosomes, chronic ethanol administration did not affect the release of ACh and of DA, while significantly decreasing the release of Glu and NA. The endogenous levels of NA, DA and their metabolites were unchanged. In hippocampal synaptosomes the only effect of chronic alcohol was an increased release of Glu. It can be concluded that at presynaptic level chronic ethanol alters brain neurotransmitter systems selectively. Glutamatergic and noradrenergic nerve terminals from cortex are more vulnerable than those from hippocampus.
Original languageEnglish
Pages (from-to)287-294
JournalAddiction Biology
Volume8
DOIs
Publication statusPublished - 1 Jan 2003

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