Abstract
The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed. © 1989.
| Original language | English |
|---|---|
| Pages (from-to) | 407-409 |
| Journal | Neuropharmacology |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jan 1989 |
Keywords
- apomorphine
- caffeine
- dopaminergic receptors
- nigrostriatal pathway lesion
- rat
- rotational behaviour