The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed. © 1989.
- dopaminergic receptors
- nigrostriatal pathway lesion
- rotational behaviour
Casas, M., Ferré, S., Cobos, A., Grau, J. M., & Jané, F. (1989). Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway. Neuropharmacology, 28(4), 407-409. https://doi.org/10.1016/0028-3908(89)90037-3