Relationship between poor decision-making process and fatigue perception in Parkinson's disease patients

Naia Sáez-Francàs, Jorge Hernández-Vara, Margarita Corominas-Roso, José Alegre, Carlos Jacas, Miguel Casas

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Background Fatigue is a common non-motor symptom in Parkinson's disease patients. The reasons for its perception are not completely understood. One suggested possibility might be that perceived fatigue is related with abnormal interpretation of somatic symptoms. It has been described that somatic markers misinterpretation leads to poor decision-making. We hypothesized that fatigued Parkinson's disease patients would show poorer performance than non-fatigued in a decision-making task. Methods To test our hypothesis, 89 Parkinson's disease patients were assessed for the presence of fatigue using the Parkinson Fatigue Scale. All patients were also administered scales evaluating psychopathology and neuropsychological tests, including the Iowa Gambling Task. Results 33 (37.1%) patients fulfilled the established criteria for fatigue. In the univariate analysis, fatigued patients showed higher levels of anxiety (state: p = 0.001, trait: p < 0.001), impulsivity (p = 0.051), and depression (p < 0.001) than non-fatigued patients. No statistically significant differences in other neuropsychological test results (Stroop, Trail Making Test, Tower of London) were found between fatigued and non-fatigued patients except for the Iowa Gambling Task, in which fatigued patients showed poorer performance (p = 0.001) after controlling for confounding factors. Conclusions These results suggest that fatigued Parkinson's disease patients may present abnormal decision-making process, which may reflect abnormal processing of somatic markers when faced with an activity that requires effort. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)167-172
JournalJournal of the Neurological Sciences
Volume337
Issue number1-2
DOIs
Publication statusPublished - 15 Feb 2014

Keywords

  • Decision-making
  • Fatigue
  • Iowa Gambling Task
  • Parkinson's disease
  • Prefrontal cortex
  • Psychopathology

Fingerprint Dive into the research topics of 'Relationship between poor decision-making process and fatigue perception in Parkinson's disease patients'. Together they form a unique fingerprint.

Cite this