Relationship between kidney size and blood pressure profile in patients with autosomal dominant polycystic kidney disease without renal failure

L. Sans Atxer, A. Roca-Cusachs, R. Torra, F. Calero, P. Arias, J. Ballarin, P. Fernández-Llama

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7 Citations (Scopus)

Abstract

Background: Enlargement of renal size plays an important role in the development of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD) and normal renal function. Methods: A 24h blood pressure monitoring (ABPM) and a renal ecography have been performed in 37 patients with ADPKD and estimated glomerular filtration rate >60 ml/min/1,73 m2 to study the relationship between renal size and an altered blood pressure profile in prehypertension stages. Results: 13 patients had normal blood pressure, 11 were diagnosed of masked hypertension, 4 had white coat hypertension and 9 had hypertension. We have found in the normotensive group with a dipper blood pressure profile a positive and statistically significant relationship between renal size and diastolic blood pressure variability. Conclusions: ABPM helps to make an early diagnosis of hypertension and to identify those patients with masked hypertension. This study suggests a relationship between renal size and a blood pressure profile linked to a major cardiovasular risk in normotensive patients with ADPKD. © 2010 Revista Nefrología. Órgano Oficial de la Sociedad Española de Nefrología.
Original languageEnglish
Pages (from-to)567-572
JournalNefrologia
Volume30
Issue number5
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Ambulatory monitoring of blood pressure
  • Autosomal dominant polycystic kidney disease
  • Blood pressure profile
  • Blood pressure variability
  • Renal size

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