Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Daniel Alcolea, Eduard Vilaplana, Jordi Pegueroles, Victor Montal, Pascual Sánchez-Juan, Andrea González-Suárez, Ana Pozueta, Eloy Rodríguez-Rodríguez, David Bartrés-Faz, Dídac Vidal-Piñeiro, Sofía González-Ortiz, Santiago Medrano, María Carmona-Iragui, Ma Belén Sánchez-Saudinós, Isabel Sala, Sofía Anton-Aguirre, Frederic Sampedro, Estrella Morenas-Rodríguez, Jordi Clarimón, Rafael BlesaAlberto Lleó, Juan Fortea

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61 Citations (Scopus)


© 2015 Elsevier Inc. Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1-42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42- (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.
Original languageEnglish
Pages (from-to)2018-2023
JournalNeurobiology of Aging
Issue number6
Publication statusPublished - 1 Jun 2015


  • Cortical thickness
  • CSF biomarkers
  • Neuroinflammation
  • Preclinical Alzheimer's disease
  • Structural MRI
  • YKL-40


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