TY - JOUR
T1 - Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
AU - Alcolea, Daniel
AU - Vilaplana, Eduard
AU - Pegueroles, Jordi
AU - Montal, Victor
AU - Sánchez-Juan, Pascual
AU - González-Suárez, Andrea
AU - Pozueta, Ana
AU - Rodríguez-Rodríguez, Eloy
AU - Bartrés-Faz, David
AU - Vidal-Piñeiro, Dídac
AU - González-Ortiz, Sofía
AU - Medrano, Santiago
AU - Carmona-Iragui, María
AU - Sánchez-Saudinós, Ma Belén
AU - Sala, Isabel
AU - Anton-Aguirre, Sofía
AU - Sampedro, Frederic
AU - Morenas-Rodríguez, Estrella
AU - Clarimón, Jordi
AU - Blesa, Rafael
AU - Lleó, Alberto
AU - Fortea, Juan
PY - 2015/6/1
Y1 - 2015/6/1
N2 - © 2015 Elsevier Inc. Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1-42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42- (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.
AB - © 2015 Elsevier Inc. Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1-42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42- (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.
KW - Cortical thickness
KW - CSF biomarkers
KW - Neuroinflammation
KW - Preclinical Alzheimer's disease
KW - Structural MRI
KW - YKL-40
U2 - 10.1016/j.neurobiolaging.2015.03.001
DO - 10.1016/j.neurobiolaging.2015.03.001
M3 - Article
VL - 36
SP - 2018
EP - 2023
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 6
ER -